2020
DOI: 10.3892/mmr.2020.11483
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Abstract: intervertebral disc degeneration (idd) is a degenerative disease of the spine originating from the intervertebral disc. Micrornas (mirnas or mirs) are a group of endogenous small non-coding rnas that act on target genes and play a critical role in numerous biological processes. However, the underlying mechanism of mir-25-3p in idd remains unclear. Therefore, the present study aimed to explore the role of mir-25-3p in the pathogenesis of idd. The results demonstrated that mir-25-3p was downregulated in rat dege… Show more

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Cited by 13 publications
(12 citation statements)
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“…In this research, we utilized bioinformatic tool to predict the potential genes interplaying with OIP5-AS1. Interestingly, miR-25-3p, assumed to be targeted by OIP5-AS1, has been reported as a suppressor for IDD [19]. Previous researches have also demonstrated the suppressive role of miR-25-3p in colorectal cancer [17] and tongue squamous cell carcinoma [18].…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…In this research, we utilized bioinformatic tool to predict the potential genes interplaying with OIP5-AS1. Interestingly, miR-25-3p, assumed to be targeted by OIP5-AS1, has been reported as a suppressor for IDD [19]. Previous researches have also demonstrated the suppressive role of miR-25-3p in colorectal cancer [17] and tongue squamous cell carcinoma [18].…”
Section: Discussionmentioning
confidence: 98%
“…MiR-25-3p also attenuates proliferation capacity of tongue squamous cell carcinoma Tca8113 cells [18]. Moreover, miR-25-3p has been indicated to enhance NPCs proliferation and apoptosis resistance in IDD by reduction of Bim [19].…”
Section: Introductionmentioning
confidence: 97%
“…In this research, we utilized bioinformatic tool to predict the potential genes interplaying with OIP5-AS1, we found that OIP5-AS1 sponged miR-25-3p. Interestingly, miR-25-3p, assumed to be targeted by OIP5-AS1, has been reported as a suppressor for IDD [ 26 ]. Additionally, although the expression of OIP5-AS1 and miR-25-3p has been testified, such relationship was first identified in IDD until our study.…”
Section: Discussionmentioning
confidence: 99%
“…Previous researches have also demonstrated the suppressive role of miR-25-3p in tongue squamous cell carcinoma and closely associated with the degradation of human nucleus pulposus cells [ 25 ]. Moreover, miR-25-3p has been indicated to enhance NPCs proliferation and apoptosis resistance in IDD by reduction of Bim [ 26 ]. Therefore, it was speculated that OIP5-AS1 bound to miR-25-3p and accelerated the progression of IDD.…”
Section: Introductionmentioning
confidence: 99%
“…A previous study has also demonstrated that high levels of lncRNA DNA polymerase ε (lncPolE) are associated with high-grade IDD, and lncPolE overexpression enhances apoptosis in human NP cells ( 16 ). In addition, accumulating evidence has indicated that microRNAs (miRNAs or miRs), another group of non-coding transcripts, are also involved in IDD by modulating NP cell proliferation and apoptosis ( 17 , 18 ). In degenerative NP cells, miR-573 inhibits apoptosis by suppressing Bax expression ( 19 ).…”
Section: Introductionmentioning
confidence: 99%