Letizia Penolazzi, Elisabetta Lambertini, Leticia Scussel Bergamin, Tosca Roncada, Pasquale De Bonis, Michele Cavallo, Roberta Piva
Abstract:The aim of this study was to investigate the role of an antichondrogenic factor, MIR221 (miR-221), in intervertebral disc degeneration (IDD), and provide basic information for the development of a therapeutic strategy for the disc repair based on specific nucleic acid based drugs, such as miR-221 silencing. We established a relatively quick protocol to minimize artifacts from extended in vitro culture, without selecting the different types of cells from intervertebral disc (IVD) or completely disrupting extrac…
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