MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence

Ramalinga, Malathi; Roy, Arpıta; Srivastava, Anshu; Bhattarai, Asmita; Harish, Varsha; Suy, Simeng; Collins, Sean P.; Kumar, Deepak

doi:10.18632/oncotarget.5920

Cited by 82 publications

(46 citation statements)

References 51 publications

(75 reference statements)

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“…The role of SIRT1 in tumors is significantly heterogeneous. In prostate cancer, SIRT1-mediated autophagy plays a role in modulating angiogenesis and cellular senescence [35], while in human breast adenocarcinoma MCF7 cells, it promoted autophagosome maturation and tumor growth [23]. It has also been reported that SIRT1 could promote autophagosome maturation by deacetylating Beclin-1 [23].…”

Section: Discussionmentioning

confidence: 99%

“…In our previously published study, we showed that SIRT1 regulates autophagy through the SIRT1-FoxO1-Rab7 axis, deacetylation of ATGs 5, 7, and 8 and other mediators, such as H4K16ac, FoxO3, E2F1, and p73 [17]. Recently, Ramalinga et al (2015) [35] demonstrated that miR-212 inhibits autophagy by inhibiting SIRT1 expression in prostate cancer cells, while transfection of cells with SIRT1 induced autophagy. In addition, SIRT1 could reduce polyglutamine cellular toxicity by inducing autophagy in SH-SY5Y cells [36].…”

Section: Discussionmentioning

confidence: 99%

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The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer

Qiu

Wei

et al. 2016

Disease Markers

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Aim. Sirtuin 1 (SIRT1) can induce autophagy through deacetylation of Beclin-1 and other autophagy mediators. However, the relationship between SIRT1 and autophagy in GC has not been defined. Therefore, the aim of this study was to confirm the prognostic value of SIRT1 and Beclin-1 and their relationship in GC patients. Methods. Transmission electron microscopy (TEM) was performed to examine the autophagy in GC patients. Immunohistochemistry was used to examine the expression of SIRT1, Beclin-1 in GC, and adjacent nonneoplastic mucosa. Results. In 7 out of 8 GC patients' samples examined by TEM, more autophagic vesicles were observed in GC tissues compared to adjacent nonneoplastic mucosa tissue. A positive correlation between SIRT1 and Beclin-1 expression was observed. Furthermore, Beclin-1 or SIRT1 expression alone or their combined expression were significantly correlated with advanced clinicopathological parameters. High Beclin-1 and SIRT1 expression alone and their combined high expression predicted shorter overall survival and relapse-free survival. Both high Beclin-1 and SIRT1 expressions were independent prognostic factors for poor survival of GC. Conclusions. Based on our results we can conclude that SIRT1 and Beclin-1 expression alone or in combination can be used as prognostic indicator and may represent new therapeutic targets in GC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer

Qiu

Wei

et al. 2016

Disease Markers

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“…32 SIRT1, which was shown to modulate both physiological and pathological processes in cells via acting on cell cycle proteins, including Rb, is now verified to be targeted by miR-212 in some cancers. 33,34 miR-212-3p was shown by Ramalinga et al 35 to prevent autophagy and angiogenesis while inducing cellular senescence by targeting SIRT1 in PCa. Likewise, it was demonstrated that miR-212-3p can suppress thyroid cancer cell growth through SIRT1.…”

Section: Mir-212 and The Cell Cyclementioning

confidence: 99%

The functions and targets of miR‐212 as a potential biomarker of cancer diagnosis and therapy

Song

Bian

Yang

et al. 2020

J Cellular Molecular Medi

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Cancer is a major health problem worldwide. An increasing number of researchers are studying the diagnosis, therapy and mechanisms underlying the development and progression of cancer. The study of noncoding RNA has attracted a lot of attention in recent years. It was found that frequent alterations of miRNA expression not only have various functions in cancer but also that miRNAs can act as clinical markers of diagnosis, stage and progression of cancer. MiR‐212 is an important example of miRNAs involved in cancer. According to recent studies, miR‐212 may serve as an oncogene or tumour suppressor by influencing different targets or pathways during the oncogenesis and the development and metastasis of cancer. Its deregulation may serve as a marker for the diagnosis or prognosis of cancer. In addition, it was recently reported that miR‐212 was related to the sensitivity or resistance of cancer cells to chemotherapy or radiotherapy. Here, we summarize the current understanding of miR‐212 functions in cancer by describing the relevant signalling pathways and targets. The role of miR‐212 as a biomarker and its therapeutic potential in cancer is also described. The aim of this review was to identify new methods for the diagnosis and treatment of human cancers.

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“…Many of these processes require the modulation of autophagy by SIRT1 (12, 40, 126, 127). SIRT1 controls stem cell survival by modulating autophagic flux (128) and SIRT1 activity is increased in conjunction with AMPK to lead to autophagy and cellular protection (129).…”

Section: Circadian Rhythm Mtor and Sirt1mentioning

confidence: 99%

Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer

Maiese¹

2017

CNR

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Background The mammalian circadian clock and its associated clock genes are increasingly be recognized as critical components for a number of physiological and disease processes that extend beyond hormone release, thermal regulation, and sleep-wake cycles. New evidence suggests that clinical behavior disruptions that involve prolonged shift work and even space travel may negatively impact circadian rhythm and lead to multi-system disease. Methods In light of the significant role circadian rhythm can hold over the body's normal physiology as well as disease processes, we examined and discussed the impact circadian rhythm and clock genes hold over lifespan, neurodegenerative disorders, and tumorigenesis. Results In experimental models, lifespan is significantly reduced with the introduction of arrhythmic mutants and leads to an increase in oxidative stress exposure. Interestingly, patients with Alzheimer's disease and Parkinson's disease may suffer disease onset or progression as a result of alterations in the DNA methylation of clock genes as well as prolonged pharmacological treatment for these disorders that may lead to impairment of circadian rhythm function. Tumorigenesis also can occur with the loss of a maintained circadian rhythm and lead to an increased risk for nasopharyngeal carcinoma, breast cancer, and metastatic colorectal cancer. Interestingly, the circadian clock system relies upon the regulation of the critical pathways of autophagy, the mechanistic target of rapamycin (mTOR), AMP activated protein kinase (AMPK), and silent mating type information regulation 2 homolog 1 (Saccharomyces cerevisiae) (SIRT1) as well as proliferative mechanisms that involve the wingless pathway of Wnt/β-catenin pathway to foster cell survival during injury and block tumor cell growth. Conclusions Future targeting of the pathways of autophagy, mTOR, SIRT1, and Wnt that control mammalian circadian rhythm may hold the key for the development of novel and effective therapies against aging- related disorders, neurodegenerative disease, and tumorigenesis.

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MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular senescence

Cited by 82 publications

References 51 publications

The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer

The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer

The functions and targets of miR‐212 as a potential biomarker of cancer diagnosis and therapy

Moving to the Rhythm with Clock (Circadian) Genes, Autophagy, mTOR, and SIRT1 in Degenerative Disease and Cancer

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