2018
DOI: 10.18632/aging.101484 View full text |Buy / Rent full text
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Abstract: Astrogliosis following spinal cord injury (SCI) was considered as a negative factor for neural regeneration. We found that miR-21 was significantly upregulated after SCI. So, we aim to determine whether miR-21 acts in a positive manner post SCI. In vitro, we measured the proliferation, apoptosis and cytokine secretion of primary cultured astrocytes after modulating the expression of miR-21 by western blot, RT-PCR and immunofluorescence. In vivo, we performed a modified Allen’s weight drop model. Manipulation o… Show more

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“…In vivo and in vitro inhibition of the TGF-β pathway blocks the function of fibrinogen in the glial scar formation [64]. It is worth mentioning that our team has found that miR-21 regulates reactive astrogliosis by TGF-β signaling at the postacute phase of SCI [65]. More recently, we demonstrated that miR-21 is a switch that regulates the polarization of astrocytes.…”
Section: Morphological Changes In Reactive Astrocytesmentioning
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“…In vivo and in vitro inhibition of the TGF-β pathway blocks the function of fibrinogen in the glial scar formation [64]. It is worth mentioning that our team has found that miR-21 regulates reactive astrogliosis by TGF-β signaling at the postacute phase of SCI [65]. More recently, we demonstrated that miR-21 is a switch that regulates the polarization of astrocytes.…”
Section: Morphological Changes In Reactive Astrocytesmentioning
“…Our previous studies suggested that miR-21 regulates astrocytic reactions after the acute phase of spinal cord injury by modulating TGF-b signaling; miR-21 was up-regulated and diminished the neuroprotection of neurons (17). Therefore, we tried to verify that silencing miR-21 would promote the neuroprotective development of astrocytes.…”
Section: Discussionmentioning
“…Accumulating evidence has implicated miR in the recovery from ischemic diseases: miR-17-3p promoted motor-induced chamber velocity, cardiac growth, and prevented disadvantageous ventricular remodeling (14). Moreover, miR-424 contributed to postischemic-induced vascular remodeling and angiogenesis (15); miR-92a may be an important therapeutic target for the treatment of heart ischemic disease in pigs (16); and miR-21 has been observed to participate in regulating astrocytic reaction to postacute spinal cord injury via the TGF-b pathway (17), thereby suggesting that miR-21 performs various vital functions in ISCI.…”
mentioning
“…Analogous effects were obtained by inducing an astrocyte miRNA, miR-21. Upon the activation of TGF-β1, miR-21 is known to induce profound positive changes in astrocyte responses, mediated by an important signaling pathway [ 52 ]. In contrast, the activation of another miRNA, miR-335-3p, was found to increase the severity of negative astrocyte responses by changing the properties of their metabolic effects [ 53 ].…”
Section: Traumatic Injuriesmentioning