2011
DOI: 10.3892/etm.2011.436
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Abstract: Abstract. microRNAs (miRNAs) are small, non-coding RNAs of endogenous origin. They have been increasingly shown to have aberrant expression in a number of tumor types. miR-192, -194 and -215 have not been comprehensively investigated using a large number of cases in colorectal cancer (CRC). We extracted total RNA from 107 CRC tissues and three CRC cell lines. Following polyadenylation and reverse transcription, the expression levels of miR-192, -194 and -215 were determined for evaluation of the association… Show more

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Cited by 88 publications
(80 citation statements)
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References 32 publications
(34 reference statements)
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“…Recent studies confirmed miR-215 downregulation in esophageal adenocarcinoma (Wijnhoven et al, 2010), colon cancer (Karaayvaz et al, 2011), and RCC (White et al, 2011). Decreased miR-215 levels in colorectal cancer were associated with increased tumor sizes and shorter disease-free survival after radical surgery (Chiang et al, 2012;Li et al, 2013). Ectopic expression of miR-215 inhibited cell proliferation and triggered cell cycle arrest at G2 phase in HCT 116 colon cancer cells (Song et al, 2010), and decreased cellular migration and invasion in a RCC cell line model (White et al, 2011).…”
Section: Discussionmentioning
confidence: 95%
“…Recent studies confirmed miR-215 downregulation in esophageal adenocarcinoma (Wijnhoven et al, 2010), colon cancer (Karaayvaz et al, 2011), and RCC (White et al, 2011). Decreased miR-215 levels in colorectal cancer were associated with increased tumor sizes and shorter disease-free survival after radical surgery (Chiang et al, 2012;Li et al, 2013). Ectopic expression of miR-215 inhibited cell proliferation and triggered cell cycle arrest at G2 phase in HCT 116 colon cancer cells (Song et al, 2010), and decreased cellular migration and invasion in a RCC cell line model (White et al, 2011).…”
Section: Discussionmentioning
confidence: 95%
“…Previous studies found that miR-192 is significantly increased in many types of cancer (39)(40)(41), but decreased in many others (42,43). Studies have also shown that p53-mediated upregulation of miR-192 prevents EMT in hepatocellular carcinoma through repression of the transcription factor ZEB2 (44).…”
Section: Discussionmentioning
confidence: 99%
“…In these studies, dramatic decreases in miR-194 expression were found in hepatocellular carcinoma (HCC; refs. 20, 21), CRC (22), gastric cancer (23), and multiple myeloma (24), suggesting its tumor-suppressive function. Chiang and colleagues also confirmed miR-194 as a tumor-suppressor gene in patients with CRC (22), whereas another study revealed a proangiogenesis function of miR-194 in HCT116 cells (25).…”
Section: Discussionmentioning
confidence: 99%
“…20, 21), CRC (22), gastric cancer (23), and multiple myeloma (24), suggesting its tumor-suppressive function. Chiang and colleagues also confirmed miR-194 as a tumor-suppressor gene in patients with CRC (22), whereas another study revealed a proangiogenesis function of miR-194 in HCT116 cells (25). Up to date, miR-192 and miR-215 have been reported to share the same "seed region" in the miRBase and HGNC websites: miR-192 and miR-194-2 are at 11q13.1 on the same chromosome, and miR-194-1 and miR-215 are at 1q41.…”
Section: Discussionmentioning
confidence: 99%