2012
DOI: 10.18632/aging.100508
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Abstract: Ageing of human skin is associated with phenotypic changes in the cutaneous cells; the major functional markers of ageing occur as consequences of dermal and epidermal cell senescence and of structural and compositional remodeling of normally long-lived dermal extracellular matrix proteins. Understanding the contribution of the dermal cells in skin ageing is a key question, since this tissue is particularly important for skin integrity and its properties can affect the epidermis. Several microRNAs have been sh… Show more

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Cited by 63 publications
(43 citation statements)
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References 89 publications
(56 reference statements)
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“…We observed a continuously increased level of miR-181a-5p during the progression of senescence. Increased expression of miR181a-5p has been reported in senescent fibroblast cells [75]. Interestingly, mir-181a-5p and other miRNAs specific to cancer are post-transcriptionally regulated by nucleolin [76] which we found deregulated both in proteomic and RPPA analysis.…”
Section: Discussionsupporting
confidence: 58%
“…We observed a continuously increased level of miR-181a-5p during the progression of senescence. Increased expression of miR181a-5p has been reported in senescent fibroblast cells [75]. Interestingly, mir-181a-5p and other miRNAs specific to cancer are post-transcriptionally regulated by nucleolin [76] which we found deregulated both in proteomic and RPPA analysis.…”
Section: Discussionsupporting
confidence: 58%
“…30,31 Overexpression of MIR152 can inhibit cancer cell proliferation, migration, and induce cellular senescence. 32,33 In this study, we observed that MIR152 alone can induce cell apoptosis. We speculate that MIR152, in addition to be involved in cisplatin-induced autophagy, may directly regulate certain known or unidentified targets, which can regulate apoptotic induction.…”
Section: Discussionmentioning
confidence: 53%
“…The senescent phenotype is acquired in vitro after multiple rounds of cell division (replicative senescence) or upon oncogene activation or oxidative stress [7]. In particular, oxidative stress is considered a major factor contributing to the aging process and leads to aberrant signaling pathways.…”
Section: Introductionmentioning
confidence: 99%