2012
DOI: 10.1177/039463201202500216
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Abstract: MicroRNAs are required for vascular smooth muscle growth, differentiation and function. MiR143-145 modulates cytoskeletal dynamics and acquisition of the contractile phenotype by smooth muscle cells. Lack of this miRNA cluster results in decreased blood pressure and reduced vasocontraction. As all these observations point to a key role for miR143-145 in the vasculature, we investigated whether miR143-145 deficiency is associated with impaired vascular tone. Vasocontraction was assessed in isolated aortic rings… Show more

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Cited by 29 publications
(25 citation statements)
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References 15 publications
(35 reference statements)
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“…The findings of the study confirm that miR-145 is an important vasculoprotective miR. Actually, miR-143/145 deficiency impairs vascular function (31). Restoration of miR-145 expression can limit neointimal formation in response to vascular injury by promoting Klf4 downregulation (6).…”
Section: Discussionsupporting
confidence: 60%
“…The findings of the study confirm that miR-145 is an important vasculoprotective miR. Actually, miR-143/145 deficiency impairs vascular function (31). Restoration of miR-145 expression can limit neointimal formation in response to vascular injury by promoting Klf4 downregulation (6).…”
Section: Discussionsupporting
confidence: 60%
“…45 The miR-143/145 cluster has been observed to play a fundamental role governing SMC differentiation during physiological and pathological events. 8,10,[15][16][17][18] Beside its ability to regulate SMC homeostasis, it is still not well understood how the miR-143/145 cluster regulates EC functions. In this report, we demonstrate that the modulation of the angiogenic potential of ECs is also due to the direct transfer of miR-143/145 from SMCs.…”
Section: Discussionmentioning
confidence: 99%
“…Other groups, [15][16][17] as well as ours, 8,10,18 have described the role of these miRNAs in the regulation of vascular homeostasis. In particular, we have demonstrated a critical role of the miR-143/145 cluster in SMC differentiation and vascular pathogenesis.…”
mentioning
confidence: 82%
“…MiRNAs are implicated in the pathogenesis of various cardiovascular diseases and have also been considered as potential targets for therapeutic intervention [2]. To date, several miRNAs have been described to finely regulate lipid metabolism and the progression and regression of atherosclerosis including miR-122, miR-33, miR-106, miR-758, miR-26, miR-370, miR-378/378*, let-7, miR-27, miR-103, miR-107, miR34a, miR-143 and miR-335 [320]. More recently, miRNAs were shown to exert their activities in cells different from those were they have been generated and also systemically.…”
Section: Introductionmentioning
confidence: 99%