Microreactor Technology in Lithium Chemistry

Nagaki, Aiichiro; Yoshida, Jun‐ichi

doi:10.1002/9783527667512.ch17

Cited by 3 publications

(2 citation statements)

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“…In the context of green chemistry [11], protecting-group free organic synthesis has received particular attention in the last years, because of atom economy [12–15] and reduction of synthetic steps [16]. It has been demonstrated by Yoshida that protecting-group-free synthesis could be feasible using flash chemistry and microreactor technology [17–18]. Recently, Yoshida and co-workers developed flash methods for the generation of highly unstable carbamoyl anions, such as carbamoyllithium, using a flow microreactor system [19].…”

Section: Reviewmentioning

confidence: 99%

Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis

Fanelli¹,

Parisi²,

Degennaro³

et al. 2017

Beilstein J. Org. Chem.

177

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Microreactor technology and flow chemistry could play an important role in the development of green and sustainable synthetic processes. In this review, some recent relevant examples in the field of flash chemistry, catalysis, hazardous chemistry and continuous flow processing are described. Selected examples highlight the role that flow chemistry could play in the near future for a sustainable development.

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Section: Reviewmentioning

confidence: 99%

Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis

Fanelli¹,

Parisi²,

Degennaro³

et al. 2017

Beilstein J. Org. Chem.

177

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show abstract

“…Seminal works by Yoshida and co-workers, demonstrated that flow microreactors enable reactions involving highly unstable organolithiums even in the presence of sensitive functional groups (i.e., carbonyl, ester, nitro groups). [14] The same author introduced the concept of flash chemistry that is defined as a field of chemical synthesis where extremely fast reactions are conducted in a highly controlled manner to produce the desired compounds with high selectivity. [15] The main advantages of microreactors and continuous flow systems lie in the improved heat and mass transfer, short residence times, precise reaction control, with possibility to automate the process, higher safety in using reactive and hazardous materials and more sustainability.…”

mentioning

confidence: 99%

External Trapping of Halomethyllithium Enabled by Flow Microreactors

et al. 2014

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This work demonstrates that the accurate control of the reaction parameters realized within microreactor systems allowed for a taming of the reactivity of thermally unstable intermediates such as haloalkyllithiums. The first example of effective external trapping of a reactive carbenoid such as the chloromethyllithium is described. By using microreactor systems, a continuous flow synthesis of chloro alcohols and chloro amines could be achieved with high yields. By controlling the residence time the highly reactive chloromethyllithium could be generated and reacted with electrophiles at temperatures much higher than in batch-mode and without internal quenching. The developed continuous-flow process matches the requirements for sustainability.

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