Microporous Nano-hydroxyapatite/collagen/phosphatidylserine Scaffolds Embedding Collagen Microparticles for Controlled Drug Delivery in Bone Tissue Engineering

Chao, Yang; Fang, Cong

doi:10.1590/1516-1439.042115

Cited by 7 publications

(7 citation statements)

References 11 publications

(12 reference statements)

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“…The profile shows a burst of drug (= 18%) on the first two day with a total of 60% to 70% of the loaded drug released from the scaffolds in 10 to 15 days, followed by slow release of bound drug starting at around 25 days. This result corresponds to our early release profiles reported for collagen microspheres [7] . Our previous study showed that the application of steroidal saponins to MC3T3-E1 cells enhanced the biomineralization and proliferation of cells [7] .…”

Section: Resultssupporting

confidence: 91%

“…This result corresponds to our early release profiles reported for collagen microspheres [7] . Our previous study showed that the application of steroidal saponins to MC3T3-E1 cells enhanced the biomineralization and proliferation of cells [7] . But the reasons by which the administration of steroidal saponins improved bioactivity in this model are vague.…”

Section: Resultssupporting

confidence: 91%

“…The steroidal saponins-loaded collagen microsphere was prepared as previously reported [7] . The steroidal saponins-loaded nBG/PS/COL scaffolds were made with similar procedure of nBG/PS/COL composite [6] .…”

Section: Preparation Of Composite Scaffoldsmentioning

confidence: 99%

“…Beside that, we previously developed a novel collagen microencapsulation technology entrapping steroidal saponins in a self-assembled collagen matrix consisting of collagen fiber meshwork. These stable microspheres provide a physiologically relevant microenvironment to support osteoblast proliferation, viability, and differentiation [7] . Therefore the possibility of using steroidal saponins as an inducer factor assures better biological performance for bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Effect of steroidal saponins-loaded composite scaffolds on bone healing

Amabye¹,

Internationals²

2016

JMCT

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The objective of this study was to investigate the therapeutic potential of nano-bioglass/phosphatidylserine/collagen scaffolds loaded with steroidal saponins as an inducer factor for skeletal defects. The drugs-encapsulated bone substitute was prepared by loading steroidal saponins-collagen microsphere suspension in nano-bioglass and phosphatidylserine composite. The scaffolds possess an interconnected porous structure with a porosity of about 82.3%. The pore size ranges from several micrometers up to about 400 μm. The drug release assays showed the long-term sustained release of steroidal saponins from the scaffolds with effective and safe bioactivity. Moreover, in vitro and in vivo studies showed that the involvement of steroidal saponins contributed to the secretion of nerve growth factor in MC3T3-E1 cells, which may be the possible factor that greatly enhanced bone healing. The results suggest that the bone substitute is an effective implantable drug-delivery system for use in bone repair.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 91%

Section: Preparation Of Composite Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of steroidal saponins-loaded composite scaffolds on bone healing

Amabye¹,

Internationals²

2016

JMCT

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“…Many polymers and biopolymers have been extensively investigated as potential materials for wound covering scaffold production. The use of natural biopolymers such as chitosan, collagen and gelatin in the construction of wound healing devices is quite attractive, mostly because of their biocompatibility, possibility of various chemical modifications, and relatively low cost of production (in many cases directly from renewable sources) [11][12][13][14][15] . Particularly, gelatin and chitosan are non-toxic, biodegradable, and biocompatible 14 .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Processing Parameters and Solid Concentration on the Microstructure and Pore Architecture of Gelatin-Chitosan Scaffolds Produced by Freeze-Drying

Angulo

Sobral

2016

Mat. Res.

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One of the main components for being successful in tissue engineering is developing a scaffold with an appropriate architecture for allow migration, cell proliferation, and differentiation. A gelatinchitosan scaffold by vacuum freeze-drying has been developed for tissue engineering applications. The effects of solid concentration and freezing processing on the scaffold morphology and porous size were investigated. As the chitosan content was increased the viscoelastic properties of pigskin gelatin was modified, the maximum G' values were lower than the values for pure gelatin solution, and the thermal transition points also occurred at lower temperatures, as well as a decrease of pore size tendency was observed and the scaffold visibly increased porosity, the structure scaffold was observed with an interconnected and more homogeneous pore matrix. The pore sizes become smaller and pore walls thinner, while interconnectivity increases along with declining pre-freezing temperature. The chitosan-gelatin scaffold will be a promising candidate in tissue engineering.

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Trends in Bioactive Biomaterials in Tissue Engineering and Regenerative Medicine

Rajalekshmy

Rekha

2021

Biomaterials in Tissue Engineering and Regenerative Medicine

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Microporous Nano-hydroxyapatite/collagen/phosphatidylserine Scaffolds Embedding Collagen Microparticles for Controlled Drug Delivery in Bone Tissue Engineering

Cited by 7 publications

References 11 publications

Effect of steroidal saponins-loaded composite scaffolds on bone healing

Effect of steroidal saponins-loaded composite scaffolds on bone healing

The Effect of Processing Parameters and Solid Concentration on the Microstructure and Pore Architecture of Gelatin-Chitosan Scaffolds Produced by Freeze-Drying

Trends in Bioactive Biomaterials in Tissue Engineering and Regenerative Medicine

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