Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
15
0

Year Published

2018
2018
2021
2021

Publication Types

Select...
6
2

Relationship

2
6

Authors

Journals

citations
Cited by 25 publications
(16 citation statements)
references
References 27 publications
1
15
0
Order By: Relevance
“…During further heating, no recrystallization or melting event was observed ( Figure 4 a). For coated amorphous CRV particles (20% ( w/w ) PS65) a weak and broad melting endotherm with the onset at 22.1 °C was measured, corresponding to the melting temperature (T m ) of PS65 [ 31 ] that was not detected for particles coated with 10% ( w/w ) PS65, indicating the limit of detection of the employed method ( Figure 4 b,c). Upon further heating, the glass transition of the amorphous CRV core was detected, which was slightly increased compared to uncoated amorphous CRV (40.0 °C for 10% ( w/w ) PS65 and 44.0 °C for 20% ( w/w ) PS65) and followed by a weak endothermic event owing to the structural relaxation of the amorphous form during storage [ 35 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…During further heating, no recrystallization or melting event was observed ( Figure 4 a). For coated amorphous CRV particles (20% ( w/w ) PS65) a weak and broad melting endotherm with the onset at 22.1 °C was measured, corresponding to the melting temperature (T m ) of PS65 [ 31 ] that was not detected for particles coated with 10% ( w/w ) PS65, indicating the limit of detection of the employed method ( Figure 4 b,c). Upon further heating, the glass transition of the amorphous CRV core was detected, which was slightly increased compared to uncoated amorphous CRV (40.0 °C for 10% ( w/w ) PS65 and 44.0 °C for 20% ( w/w ) PS65) and followed by a weak endothermic event owing to the structural relaxation of the amorphous form during storage [ 35 ].…”
Section: Resultsmentioning
confidence: 99%
“…The crystalline hydrate form of CRV was only detected in samples that were stored at 75% rH, enabling the required water uptake for the observed hydrate formation. Coating formulations of tripalmitin and PS65 have previously been shown to be able to take up significant amounts of water due to the more hydrophilic character of PS65 (HLB 10.5) compared to the triglyceride tripalmitin [31]. To obtain effective protection of the coated particles from storage humidity, neat tripalmitin as the coating material would have to be used.…”
Section: Solid-state Characterization Of Amorphous Particles Using Xrpdmentioning
confidence: 99%
“…In agreement with the DSC analysis, MPs melted at temperatures of 55-60 • C, but the melting was not complete and the MPs remained partially solid. Then, the melted tristearin re-crystallized at 63 • C, followed by a complete melting at 70-72 • C. In the following cooling step, the melt started to crystallize at 51 • C with the appearance of spherulities, 3-D structures composed of oriented anisotropic lamellar crystallites [17,40]. Spherulities grew separately from the melt as each of them originates from a different nucleus [45].…”
Section: Microstructural Levelmentioning
confidence: 99%
“…These techniques, based on the melting of the lipid followed by re-solidification, can cause the formation of unstable crystalline phases with the tendency to evolve into more stable states during storage. This instability, related to the complex solid state behavior of these materials, is a well-known issue of lipid-containing dosage forms [ 2 , 17 , 18 , 19 ]. It is therefore very important to have control over the type of crystalline structure of the lipid-based product during its whole shelf life.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the lipid-based coating provides suitable taste masking and a modified release [1,2]. The challenge of lipid-based formulations is, however, their instability during storage [3]. During the last decades, a large body of investigations showed the correlation between the monotropic polymorphism of lipids and the instability of their pharmaceutical products [3][4][5][6][7][8][9][10].…”
Section: Introductionmentioning
confidence: 99%