Micropatterning of Polymer Thin Films with pH-Sensitive and Cross-linkable Hydrogen-Bonded Polyelectrolyte Multilayers

Yang, Sung Yun; Rubner, Michael F.

doi:10.1021/ja017681y

Cited by 388 publications

(363 citation statements)

References 11 publications

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“…Early attempts for selective multilayer assembly on specific areas involve microcontact printing through the use of self-assembled monolayers (SAMs) as molecular templates [69,70]. Later, non-lithographical means such as inkjet printing were introduced [71]. The development of new techniques, such as the ''lift-off'' approach [72], and the ''polymer on polymer'' stamping [73] were followed.…”

Section: Surface Patterningmentioning

confidence: 99%

Electrostatic Assembly with Poly(ferrocenylsilanes)

Hempenius

Vancso

2007

J Inorg Organomet Polym

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New frontiers in polymer science involve the incorporation of functional species into material systems. The electrostatic layer-by-layer (LBL) self-assembly technique constitutes a versatile tool for nano-and microscale fabrication of devices and novel material structures. Although a rapidly growing attention has been paid to this area, most of the studies conducted were based on organic polymeric electrolytes. Due to synthetic developments, new polymeric structures with inorganic elements and transition metals incorporated in the main chain have become accessible. With the development of new synthesis routes, organometallic poly(ferrocenylsilane) polycations and polyanions emerged. Their charged nature and water-solubility made them excellent candidates for the extension of electrostatic multilayer assembly to organometallic polymeric materials. The present review gives a concise summary on the LBL fabrication of organometallic thin films and microcapsules based on water-soluble poly(ferrocenylsilane) polyions. The unique functions of these structures come from the molecular structure of poly(ferrocenylsilanes), in which silicon atoms and redoxactive ferrocene units are present. In this context, the diverse application potentials of these organometallic multilayer structures are also discussed.

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Section: Surface Patterningmentioning

confidence: 99%

Electrostatic Assembly with Poly(ferrocenylsilanes)

Hempenius

Vancso

2007

J Inorg Organomet Polym

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“…As well-known, electrostatic interaction is the most common driving force to build self-assembly multilayer films [40]. Water-soluble and multiple charge are required for the components to construct the electrostatic LbL multilayers.…”

Section: Fabrication Of Multilayer Films Via Electrostatic Interactionmentioning

confidence: 99%

Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions

Li¹,

He²,

Wang³

et al. 2014

Express Polym. Lett.

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Abstract. By combining LbL (layer-by-layer) self-assembly approach and host-guest interactions, a unique multilayer film was constructed and employed for a light-controlled drug release system. The drug molecules can be loaded and released into the resulting polyelectrolyte multilayers containing azobenzene (Azo) function groups by using the irradiation of visible light and UV light alternately. The photo-sensitivity of the multilayer films was studied through UV-vis spectrum, fluorescence spectrum and confocal microscopy. The target molecules could be rapidly released from the multilayers after 300 W UV light irradiation for 20 minutes. Moreover, they could be readsorbed into the multilayers uniformly when illuminated under the 300 W visible light for 10 minutes confirmed by the observation of confocal microscopy, and the readsorption ratio exceeds 100% evidenced from UV-vis spectroscopy. After several cycles of the above-mentioned process, the multilayer films show good fatigue resistance. All these results indicate the photo-sensitivity and high-efficiency of the multilayer films, which have great potential in controlled drug delivery platform and biomedical applications. : coatings, layer-by-layer, host-guest interactions, light response, drug delivery eXPRESS Polymer Letters Vol.8, No.3 (2014) 143-153 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2014.18 * Corresponding author, e-mail: softmatter@163.com © BME-PT nating irradiation with UV and Vis light allows for reversible sliding of !-CD along the surfactant, leading to the formation of rotaxane-like vesicles. Based on this principle, light-responsive host-guest assembly and disassembly between Azo and CD hold great potential to design a reversible drug delivery profile [16,17]. Layer-by-layer (LbL) self-assembly approach is particularly well-suited for fabricating functional multilayer thin films with ultrafine nanometer-scale structure for use as drug delivery vehicles [18][19][20][21]. The traditional means of loading drugs on layers of LbL platform always uses physical adsorption or chemical bonding. However, these methods of loading drugs have a common drawback: drug loading and release is irreversible. This is a critical problem in LbL multilayers for drug delivery. Therefore, it's desired to devise a reversible LbL-based system to manipulate the drug release in a more controllable manner. In the past decade, the pioneering work on LbL assembly with supramolecular interaction has been established by Ikeda et al. [22]. Subsequently, Smith et al. [23] have reported that loading smallmolecule drugs on the layers of LbL-based system using supramolecular interaction. On another front, the light-induced drug release from a LbL-based system is the most elegant way to combine reversibly and efficiency, because light as an attractive stimulus can be applied rapidly, remotely, and locally [24,25]. While numerous well-established photoresponsive LbL-based systems are available [26,27], their applications in drug release b...

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“…According to observations, the patterns are stable in aqueous solution and cell culture media for at least 5 weeks, with no apparent loss of fluorescence intensity, which agrees with other reports on the stability of multilayer nanofilms. 33,66,67 For observations performed up to 2 weeks in vitro, it was found that neurons preferentially bound to {PSS/PDDA} 3 /{sPLA 2 /(FITC-PEI) 4 }/sPLA 2 patterns compared with {PSS/ PDDA} 3 /{PSS/(TRITC-PLL)} 5 patterns. In addition, large and fine neuronal processes were observed, following preferential localization of cells on the FITC patterns.…”

Section: Cell Culturementioning

confidence: 99%

Fabrication of Interdigitated Micropatterns of Self-Assembled Polymer Nanofilms Containing Cell-Adhesive Materials

2006

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Micropatterns of different biomaterials with micro-and nanoscale features and defined spatial arrangement on a single substrate are useful tools for studying cellular-level interactions, and recent reports have highlighted the strong influence of scaffold compliance in determining cell behavior. In this paper, a simple yet versatile and precise patterning technique for the fabrication of interdigitated micropatterns of nanocomposite multilayer coatings on a single substrate is demonstrated through a combination of lithography and layer-by-layer (LbL) assembly processes, termed as Polymer Surface Micromachining (PSM). The first nanofilm pattern is constructed using lithography, followed by LbL multilayer assembly and lift-off, and the process is repeated with optical alignment to obtain interdigitated patterns on the same substrate. Thus, the method is analogous to surface micromachining, except that the deposition materials are polymers and biological materials that are used to produce multilayer nanocomposite structures. A key feature of the multilayers is the capability to tune properties such as stiffness by appropriate selection of materials, deposition conditions, and post-deposition treatments. Two-and four-component systems on glass coverslips are presented to demonstrate the versatility of the approach to construct preciselydefined, homogeneous nanofilm patterns. In addition, an example of a complex system used as a testbed for in vitro cell adhesion and growth is provided: micropatterns of poly(sodium 4-styrenesulfonate)/poly-L-lysine hydrobromide (PSS/PLL) and secreted phospholipase A 2 /poly (ethyleneimine) (PEI/sPLA 2 ) multilayers. The interdigitated square nanofilm array patterns were obtained on a single coverslip with poly(diallyldimethyl ammonium chloride) (PDDA) as a cellrepellent background. Cell culture experiments show that cortical neurons respond and bind specifically to the sPLA 2 micropatterns in competition with PLL micropatterns. The fabrication and the initial biological results on the nanofilm micropatterns support the usefulness of the technique for use in studies aimed at elucidating important biological structure-function relationships, but the applicability of the fabrication method is much broader and may impact electronics, photonics, and chemical microsystems.

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Micropatterning of Polymer Thin Films with pH-Sensitive and Cross-linkable Hydrogen-Bonded Polyelectrolyte Multilayers

Cited by 388 publications

References 11 publications

Electrostatic Assembly with Poly(ferrocenylsilanes)

Electrostatic Assembly with Poly(ferrocenylsilanes)

Light-controlled drug releasing polymer films combining LbL self-assembly and host-guest interactions

Fabrication of Interdigitated Micropatterns of Self-Assembled Polymer Nanofilms Containing Cell-Adhesive Materials

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