Microorganisms as Antineoplastic Agents in CNS Tumors

A rare case of concurrent herpes simplex encephalitis and glioblastoma multiforme

“…[28] This phenomenon remains rare with limited published data and mostly pertaining to bacterial infections. Other than one case report, [29] no such evidence was found regarding viral infections and primary brain tumors. On the contrary, HSV infection has generally been associated with a poor outcome as also has been shown in our case.…”

“…[ 28 ] This phenomenon remains rare with limited published data and mostly pertaining to bacterial infections. Other than one case report,[ 29 ] no such evidence was found regarding viral infections and primary brain tumors.…”

A rare case of concurrent herpes simplex encephalitis and glioblastoma multiforme

“…[28] This phenomenon remains rare with limited published data and mostly pertaining to bacterial infections. Other than one case report, [29] no such evidence was found regarding viral infections and primary brain tumors. On the contrary, HSV infection has generally been associated with a poor outcome as also has been shown in our case.…”

“…[ 28 ] This phenomenon remains rare with limited published data and mostly pertaining to bacterial infections. Other than one case report,[ 29 ] no such evidence was found regarding viral infections and primary brain tumors.…”

The effect of postoperative infection on survival in patients with glioblastoma

“…A literature search found 9 patients in case reports or case series with intracranial tumors that had prolonged survival associated with postoperative infections. 2,8,11,12,19 Of these case reports, only 2 patients had glioblastoma, with others having high-grade (III or above) astrocytomas.…”

Spontaneous Involution of a Diencephalic Astrocytoma

“…In fact, deliberate innoculation of wounds with pus was once advocated as a useful adjunct in cancer operations. In the same vein, neurosurgical lore has held that patients with brain tumors and bone-flap osteomyelitis fared better than those without this infectious complication [13]. Presumably, any anticancer activity of infection would be explained, at least in part, by the stimulation of natural immune mechanisms [10,13,14].…”

“…In the same vein, neurosurgical lore has held that patients with brain tumors and bone-flap osteomyelitis fared better than those without this infectious complication [13]. Presumably, any anticancer activity of infection would be explained, at least in part, by the stimulation of natural immune mechanisms [10,13,14]. Accordingly, the relationship between cancer and the immune system has become an area of intense experimentation; however, a review of the broad subject of immunotherapy is beyond the scope of this paper.…”

A rare case of concurrent herpes simplex encephalitis and glioblastoma multiforme

“…[28] This phenomenon remains rare with limited published data and mostly pertaining to bacterial infections. Other than one case report, [29] no such evidence was found regarding viral infections and primary brain tumors. On the contrary, HSV infection has generally been associated with a poor outcome as also has been shown in our case.…”

“…[ 28 ] This phenomenon remains rare with limited published data and mostly pertaining to bacterial infections. Other than one case report,[ 29 ] no such evidence was found regarding viral infections and primary brain tumors.…”

The effect of postoperative infection on survival in patients with glioblastoma

“…A literature search found 9 patients in case reports or case series with intracranial tumors that had prolonged survival associated with postoperative infections. 2,8,11,12,19 Of these case reports, only 2 patients had glioblastoma, with others having high-grade (III or above) astrocytomas.…”

Spontaneous Involution of a Diencephalic Astrocytoma

“…In fact, deliberate innoculation of wounds with pus was once advocated as a useful adjunct in cancer operations. In the same vein, neurosurgical lore has held that patients with brain tumors and bone-flap osteomyelitis fared better than those without this infectious complication [13]. Presumably, any anticancer activity of infection would be explained, at least in part, by the stimulation of natural immune mechanisms [10,13,14].…”

“…In the same vein, neurosurgical lore has held that patients with brain tumors and bone-flap osteomyelitis fared better than those without this infectious complication [13]. Presumably, any anticancer activity of infection would be explained, at least in part, by the stimulation of natural immune mechanisms [10,13,14]. Accordingly, the relationship between cancer and the immune system has become an area of intense experimentation; however, a review of the broad subject of immunotherapy is beyond the scope of this paper.…”

A rare case of concurrent herpes simplex encephalitis and glioblastoma multiforme

“…[28] This phenomenon remains rare with limited published data and mostly pertaining to bacterial infections. Other than one case report, [29] no such evidence was found regarding viral infections and primary brain tumors. On the contrary, HSV infection has generally been associated with a poor outcome as also has been shown in our case.…”

“…[ 28 ] This phenomenon remains rare with limited published data and mostly pertaining to bacterial infections. Other than one case report,[ 29 ] no such evidence was found regarding viral infections and primary brain tumors.…”

The effect of postoperative infection on survival in patients with glioblastoma

“…A literature search found 9 patients in case reports or case series with intracranial tumors that had prolonged survival associated with postoperative infections. 2,8,11,12,19 Of these case reports, only 2 patients had glioblastoma, with others having high-grade (III or above) astrocytomas.…”

Spontaneous Involution of a Diencephalic Astrocytoma

“…In fact, deliberate innoculation of wounds with pus was once advocated as a useful adjunct in cancer operations. In the same vein, neurosurgical lore has held that patients with brain tumors and bone-flap osteomyelitis fared better than those without this infectious complication [13]. Presumably, any anticancer activity of infection would be explained, at least in part, by the stimulation of natural immune mechanisms [10,13,14].…”

“…In the same vein, neurosurgical lore has held that patients with brain tumors and bone-flap osteomyelitis fared better than those without this infectious complication [13]. Presumably, any anticancer activity of infection would be explained, at least in part, by the stimulation of natural immune mechanisms [10,13,14]. Accordingly, the relationship between cancer and the immune system has become an area of intense experimentation; however, a review of the broad subject of immunotherapy is beyond the scope of this paper.…”