Microneedling: Where do we stand now? A systematic review of the literature

Ramaut, Lisa; Hoeksema, Henk; Pirayesh, Ali; Stillaert, Filip; Monstrey, Stan

doi:10.1016/j.bjps.2017.06.006

Cited by 104 publications

(112 citation statements)

References 40 publications

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“…The activation of non‐inflammatory wound healing can induce collagen formation, neovascularization and growth factor production of treated areas, which all benefit hair restoration. Microneedling can also facilitate the penetration of minoxidil, thus making more profits than monotherapy 36,37 . However, due to the variability in the devices and administration, there exists high level of heterogeneity in assessment.…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis

Zhou

Chen

et al. 2020

Dermatologic Therapy

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Androgenetic alopecia (AGA) is the most common type of baldness affecting both men and women. Studies investigating combination therapies for AGA reported greater efficacy than monotherapy but without rigorous examination. The authors performed a meta‐analysis and systemic review to further verify the evidence. To evaluate the effectiveness of three common combination therapies of minoxidil with finasteride, low‐level laser light therapy (LLLT) or microneedling versus minoxidil monotherapy. We conducted a systematic review of randomized controlled trials (RCTs) of combination therapies consisting of topical minoxidil for AGA through April 2020. Quality assessment and data analysis were performed by Review Manager 5.3. Fifteen studies met the inclusion criteria involving a total of 1172 AGA patients. We conducted meta‐analysis for three groups of combined treatment separately, and all were superior to monotherapy in terms of global photographic assessment (P < .05). Combination of LLLT or microneedling with minoxidil also showed significant increase in hair count (P < .05) compared to monotherapy. The present study suggests that combination therapy could be an effective, safe and promising option for the treatment of AGA. However, more RCTs are needed to further investigate and confirm the efficacy of combined treatment.

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Section: Discussionmentioning

confidence: 99%

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis

Zhou

Chen

et al. 2020

Dermatologic Therapy

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“…are often added in conjunction with microneedling to enhance its penetration and effects. 5 Hyaluronic acid, when used as an adjuvant, has been shown to improve patient outcomes after minimally invasive dermatologic procedures by restoring moisture, texture, and overall appearance of the skin. 6 We explored the use of microneedling in conjunction with hyaluronic acid and salicylic acid after standard therapy failed.…”

Section: Discussionmentioning

confidence: 99%

Improvement of nevus comedonicus after repeated microneedling

et al. 2020

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“…Dissolvable but also permanent, MNs have been www.advancedsciencenews.com www.advtherap.com demonstrated to be well tolerated and easy to use. [51][52][53] MN-based insulin delivery systems are reviewed in the paper of Chen et al, which reports on the full chain from the materials to the commercial devices available on the market. [49,50] In both cases, the self-administration and painlessness of MNs greatly improved the efficacy of treatments.…”

Section: Translational Challengesmentioning

confidence: 99%

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

Dardano

Battisti²,

Rea

et al. 2019

Advanced Therapeutics

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Mainly designed and realized as a painless alternative to the hypodermic syringe, microneedle-based devices are currently approaching commercial market placement. The considerable academic and industrial investment in this technology is reflected by a multitude of papers published and patents registered every year, which is also a sign of a field in full fermentation. New materials and innovative methodologies are continuously exploited in search of the best performance at the lowest cost. For these reasons, an updated review, focused predominantly on the last year of scientific production, is a useful guideline in this rapidly changing panorama. This report provides a critical review of microneedle technologies presented in the very recent literature with a particular focus on those closest to the needs of the healthcare field. Although a few devices are already commercial, further effort is still needed to achieve complete clinical translation and therapeutic efficacy competitive with or superior to those of the devices used as standards and adopted by national health systems.

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Microneedling: Where do we stand now? A systematic review of the literature

Cited by 104 publications

References 40 publications

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis

Improvement of nevus comedonicus after repeated microneedling

Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration

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