Microneedle‐mediated Drug Delivery

Quinn, Helen L.; Donnelly, Ryan F.

doi:10.1002/9781119305101.ch3

Cited by 4 publications

(2 citation statements)

References 87 publications

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“…However, due to the small size of the needles and the fact that capacity of liquid drugs is limited to what can be coating onto the surface of the MN arrays, as a consequence, the loading volume of this type of MN is also limited. Therefore, coated MN arrays are more limited to low dose drug molecules (Quinn & Donnelly, 2018).…”

Section: Microneedle Technologymentioning

confidence: 99%

Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery

Permana

Nainu

Moffatt

et al. 2021

WIREs Nanomed Nanobiotechnol

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Numerous diseases have been reported to affect the lymphatic system. As such, several strategies have been developed to deliver chemotherapeutics to this specific network of tissues and associated organs. Nanotechnology has been exploited as one of the main approaches to improve the lymphatic uptake of drugs. Different nanoparticle approaches utilized for both active and passive targeting of the lymphatic system are discussed here. Specifically, due to the rich abundance of lymphatic capillaries in the dermis, particular attention is given to this route of administration, as intradermal administration could potentially result in higher lymphatic uptake compared to other routes of administration. Recently, progress in microneedle research has attracted particular attention as an alternative for the use of conventional hypodermic injections. The benefits of microneedles, when compared to intradermal injection, are subsequently highlighted. Importantly, microneedles exhibit particular benefit in relation to therapeutic targeting of the lymphatic system, especially when combined with nanoparticles, which are further discussed. However, despite the apparent benefits provided by this combination approach, further comprehensive preclinical and clinical studies are now necessary to realize the potential extent of this dual‐delivery platform, further taking into consideration eventual usability and acceptability in the intended patient end‐users. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Section: Microneedle Technologymentioning

confidence: 99%

Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery

Permana

Nainu

Moffatt

et al. 2021

WIREs Nanomed Nanobiotechnol

Self Cite

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“…With this, as mentioned previously, a balance must be struck between drug quantity and needle strength. Increasing the amount of coated insulin might affect he mechanical strength of MN arrays [126]. Perhaps, with a more concentrated form of insulin, therapeutic doses using a relatively small, coated MN array device could be achieved.…”

Section: Coated Mn Arraysmentioning

confidence: 99%

The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis

McAlister

Kirkby

Domínguez-Robles

et al. 2021

Advanced Drug Delivery Reviews

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The Role of 3D Printing Technology in Microengineering of Microneedles

Detamornrat

McAlister

Hutton

et al. 2022

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trademark of the company Aprecia Pharmaceuticals, LLC., Ohio, USA. Recently, Triastek has received Investigational New Drug (IND) approval from the US FDA for T19, their first 3D printed drug product designed to treat rheumatoid arthritis. [13] As a result of this approval, research into 3D printing for drug delivery has continued to rapidly expand, with several commercially available 3D printers emerging. [14][15][16][17][18][19] More recently, 3D printing has shown its promising potential in the mass production of face masks and face shields in the middle of the 2020 global pandemic when these items were in high demand for protecting healthcare professionals in the fight against COVID-19. [20,21] Generally, the fabrication of complex structures by 3D printing involves the creation of a prototype in computer-aided design (CAD) software, which is subsequently exported as a standard tessellation language (STL) file and sent to the 3D printer. [16,22] The 3D printer's software divides the 3D model data into consecutive 2D slices to facilitate the fabrication of each structure in a layerby-layer manner. Additionally, 3D scanners can also be used to record objects or body parts in the form of digital 3D images. [23] Likewise, X-rays, magnetic resonance imaging (MRI) and computerized tomography (CT) scans produce 2D radiographic images that can be converted to digital 3D model files for the fabrication of personalized anatomical structures. [1,2,6,[24][25][26][27][28] In recent years, the use of 3D printing technology to produce tailor-shaped MNs has gained great attention. MNs are a noninvasive device consisting of multiple micron-sized needles on a single patch, ranging most commonly in height from 25 to 2000 µm. [29] Upon skin insertion, MNs create temporary microscopic channels in the epidermis to either deliver drug molecules via diffusion into the microcirculation or to collect interstitial fluid (ISF) for disease diagnosis and monitoring. [30][31][32][33] As a drug delivery platform, MNs combine the patient-friendly benefits of a transdermal patch with the potential delivery capabilities of a hypodermic injection. The unique attribute of MNs is that they are strong enough to penetrate the resilient skin barrier, the stratum corneum (SC), sufficiently to enable access to the skin's rich microcirculation, yet are short and narrow enough to avoid stimulation with nerve fibers or puncture blood vessels that primarily reside in the dermal layer. Painless application is thus considered the principal benefit of MNs. [34][35][36] Microneedles (MNs) are minimally invasive devices, which have gained extensive interest over the past decades in various fields including drug delivery, disease diagnosis, monitoring, and cosmetics. MN geometry and shape are key parameters that dictate performance and therapeutic efficacy, however, traditional fabrication methods, such as molding, may not be able to offer rapid design modifications. In this regard, the fabrication of MNs using 3D printing technology enables the rapid creation ...

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Microneedle‐mediated Drug Delivery

Cited by 4 publications

References 87 publications

Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery

Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery

The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis

The Role of 3D Printing Technology in Microengineering of Microneedles

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