Microglial Transforming Growth Factor-β Signaling in Alzheimer’s Disease
Natascha Vidovic,
Björn Spittau
Abstract:Novel technologies such as single-cell RNA and single-nucleus RNA sequencing have shed new light on the complexity of different microglia populations in physiological and pathological states. The transcriptomic profiling of these populations has led to the subclassification of specific disease-associated microglia and microglia clusters in neurodegenerative diseases. A common profile includes the downregulation of homeostasis and the upregulation of inflammatory markers. Furthermore, there is concordance in fe… Show more
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