Microfluidics for advanced drug delivery systems

Riahi, Reza; Tamayol, Ali; Shaegh, Seyed Ali Mousavi; Ghaemmaghami, Amir M.; Dokmeci, Mehmet R.; Khademhosseini, Ali

doi:10.1016/j.coche.2014.12.001

Cited by 198 publications

(135 citation statements)

References 72 publications

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“…Aqueouse phase was 0.9% sodium clorid solution. MHF device used in the studyisshown in the Figure 1, which is similar to the device in the reference 17 . Solvent and aqueous phases were heated to 65 o C using a water bath before mixing.…”

Section: Methods Preparation Of Amb Lipid Complexmentioning

confidence: 66%

“…In general, lipid complex of AmB were shown to be less toxic than deoxycholate formulation while retain activity 4 . Microfluidic method is a mixing technique, which permits millisecond mixing at the nano/ microliter scale, can reproducibly generate limit size of particles of drug delivery system 5 . Thus, microfluidic systems have been increasingly used for fabrication of drug carriers such as liposomes, polymer nanoparticles, emulsion etc.…”

Section: Introductionmentioning

confidence: 99%

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A facile microfluidic method for production of amphotericin B lipid complex

Yen¹,

Duong²,

L³

et al. 2017

Pharm Sci Asia

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Amphotericin B (AmB) is a large amphiphilic molecule, which is a drug of choice in therapy of systemic fungal infection because of its board-spectrum antifungal activity. However, conventional formulation of AmB is micelles, which is unstable in the bloodstream and releases drug to form toxic aggregates. Lipid complex of AmB has been developed to reduce toxicity while retaining activity. Microfluidic method is mixing technique, which permits millisecond mixing at the nano/microliter scale, can reproducibly generate limit size of particles of drug delivery system. In this study, microfluidic hydrodynamic focusing method was used to produce AmB lipid complex. It was obtained of two synthetic phospholipids: hydrogenated soy phosphatidylcholine (HSPC), distearoylphosphatidylglycerol (DSPG) and AmB in the molar ratio of 1:1:2.The lipid complex of AmB was characterized using differential scanning calorimetry (DSC), X -ray diffraction, Fourier-transform infrared spectroscopy (FTIR) and Field Emission Scanning Electron Microscopy(FESEM).The results showed that AmB lipid complex, prepared by microfluidic method, had smallest size at the flow rate ratio (FRR) of 5:1. The distinct phase transition temperature, the crystal peak of phospholipid, the characteristic band of-P-O-group of phospholipid were not observed in the DSC curve, X-ray diffraction diagram and FTIR spectra, respectively, of AmB lipid complex.

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Section: Methods Preparation Of Amb Lipid Complexmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

A facile microfluidic method for production of amphotericin B lipid complex

Yen¹,

Duong²,

L³

et al. 2017

Pharm Sci Asia

View full text Add to dashboard Cite

show abstract

“…The smaller length scales, in comparison with conventional systems, reduce the diffusion time of reagents and the required time for assays. In addition, miniaturized systems require less reagents and sample size in comparison with conventional tests (Riahi et al 2015). These miniaturized systems are also portable and can easily be multiplexed for parallel detection of various diseases.…”

Section: Miniaturized and Point Of Care Diagnostic Toolsmentioning

confidence: 99%

Biomarkers and diagnostic tools for detection of Helicobacter pylori

Khalilpour

Kazemzadeh-Narbat

Tamayol

et al. 2016

Appl Microbiol Biotechnol

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Helicobacter pylori is responsible for worldwide chronic bacterial infection in humans affecting approximately half of the world's population. H. pylori is associated with significant morbidity and mortality including gastric cancer. The infection has both direct and indirect impacts on economic and overall well-being of patients; hence, there is a great need for diagnostic markers that could be used in the development of diagnostic kits. Here, we briefly review general aspects of H. pylori infection and the diagnostic biomarkers used in laboratory tests today with a focus on the potential role of microfluidic systems in future immunodiagnosis platforms.

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“…Recent exciting developments in stimuli-responsive materials, and particularly stimuli responsive polymers and surfaces make microfluidics a great platform for demonstrating the capabilities and highlighting the functionality of these materials. [16,17] Indeed, the microfluidic platform generally enhances the functionality of smart materials by offering faster kinetics and shorter reaction times due to increased surface to volume ratios; improved interfacial and chemical interactions; dominant surface tension and capillarity effects and efficient absorption of electro-magnetic radiation.…”

Section: Introductionmentioning

confidence: 99%

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

Dunne¹,

Francis²,

Delaney³

et al. 2017

Reference Module in Materials Science and Materials Engineering

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Integration of stimuli-responsive materials into microfluidic systems provides a means to locally manipulate flow at the microscale, in a non-invasive manner, while also reducing system complexity. In recent years, several modes of stimulation have been applied, including electrical, magnetic, light and temperature, among others. To achieve remote control of flow in microfluidics using external stimulation, two main approaches have emerged in the recent years: 1. Control of flow through stimuli-induced actuation of microfluidic components (valves, pumps, mixers, flow sorters), most often fabricated from soft polymeric materials; 2. Stimuli-controlled manipulation of discrete micrometer-sized "vehicles" (droplets, beads, Janus particles, etc.) through localized induced changes in wettability or surface tension.The focus of this chapter will be to identify and compare the similarities and underlying mechanisms employed in the current state of the art research in stimuli-controlled fluid control and micro-vehicle movement fields. It will also endeavor to propose possible directions for the evolution of these areas of research.

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Microfluidics for advanced drug delivery systems

Cited by 198 publications

References 72 publications

A facile microfluidic method for production of amphotericin B lipid complex

A facile microfluidic method for production of amphotericin B lipid complex

Biomarkers and diagnostic tools for detection of Helicobacter pylori

Stimuli-Controlled Fluid Control and Microvehicle Movement in Microfluidic Channels

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