Microfluidic-Based Single-Cell Study: Current Status and Future Perspective

Wu, Haiwa; Zhu, Jing; Huang, Yao; Wu, Dezhen; Sun, Jingyao

doi:10.3390/molecules23092347

Cited by 26 publications

(13 citation statements)

References 171 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polymer materials are now widely used to fabricate the MNs because polymers are inexpensive and easy to mass production due to their uncomplicated fabrication and low cost. 1,3,[141][142][143] The most common manufacturing technique for polymeric MNs is micromolding method, including hot embossing, injection, and casting. [144][145][146][147][148] After the master mold for MNs are fabricated, MNs can be produced efficiently and stably via micromolding techniques until the mold breaks.…”

Section: Fabrication Of Polymeric Mnsmentioning

confidence: 99%

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Sun

Zhuang

et al. 2019

Dose-Response

Self Cite

View full text Add to dashboard Cite

Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

show abstract

Section: Fabrication Of Polymeric Mnsmentioning

confidence: 99%

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Sun

Zhuang

et al. 2019

Dose-Response

Self Cite

View full text Add to dashboard Cite

show abstract

“…Metal nanoparticles have antibacterial properties, electrical conductivity, optical polarizability and good chemical properties. Metal-based nanocomposites undergo a reduction in size and functionalization of surface, which can also be exploited in plasmonic and sensing applications [ 192 , 193 ].…”

Section: Multi-functional Properties Of Bio-based Composites and Tmentioning

confidence: 99%

Conductive Polymer Composites from Renewable Resources: An Overview of Preparation, Properties, and Applications

et al. 2019

Self Cite

View full text Add to dashboard Cite

This article reviews recent advances in conductive polymer composites from renewable resources, and introduces a number of potential applications for this material class. In order to overcome disadvantages such as poor mechanical properties of polymers from renewable resources, and give renewable polymer composites better electrical and thermal conductive properties, various filling contents and matrix polymers have been developed over the last decade. These natural or reusable filling contents, polymers, and their composites are expected to greatly reduce the tremendous pressure of industrial development on the natural environment while offering acceptable conductive properties. The unique characteristics, such as electrical/thermal conductivity, mechanical strength, biodegradability and recyclability of renewable conductive polymer composites has enabled them to be implemented in many novel and exciting applications including chemical sensors, light-emitting diode, batteries, fuel cells, heat exchangers, biosensors etc. In this article, the progress of conductive composites from natural or reusable filling contents and polymer matrices, including (1) natural polymers, such as starch and cellulose, (2) conductive filler, and (3) preparation approaches, are described, with an emphasis on potential applications of these bio-based conductive polymer composites. Moreover, several commonly-used and innovative methods for the preparation of conductive polymer composites are also introduced and compared systematically.

show abstract

“…PDMS is a transparent elastic polymer with excellent biocompatibility [90,91,92]. It has been approved by the US National Heart, Lung, and Blood Institute to be a discriminatory tool for validating the evaluation of biomaterials [38].…”

Section: Biodegradable and Biocompatible Polymersmentioning

confidence: 99%

Application of Biodegradable and Biocompatible Nanocomposites in Electronics: Current Status and Future Directions

et al. 2019

Self Cite

View full text Add to dashboard Cite

With the continuous increase in the production of electronic devices, large amounts of electronic waste (E-waste) are routinely being discarded into the environment. This causes serious environmental and ecological problems because of the non-degradable polymers, released hazardous chemicals, and toxic heavy metals. The appearance of biodegradable polymers, which can be degraded or dissolved into the surrounding environment with no pollution, is promising for effectively relieving the environmental burden. Additionally, biodegradable polymers are usually biocompatible, which enables electronics to be used in implantable biomedical applications. However, for some specific application requirements, such as flexibility, electric conductivity, dielectric property, gas and water vapor barrier, most biodegradable polymers are inadequate. Recent research has focused on the preparation of nanocomposites by incorporating nanofillers into biopolymers, so as to endow them with functional characteristics, while simultaneously maintaining effective biodegradability and biocompatibility. As such, bionanocomposites have broad application prospects in electronic devices. In this paper, emergent biodegradable and biocompatible polymers used as insulators or (semi)conductors are first reviewed, followed by biodegradable and biocompatible nanocomposites applied in electronics as substrates, (semi)conductors and dielectrics, as well as electronic packaging, which is highlighted with specific examples. To finish, future directions of the biodegradable and biocompatible nanocomposites, as well as the challenges, that must be overcome are discussed.

show abstract

Microfluidic-Based Single-Cell Study: Current Status and Future Perspective

Cited by 26 publications

References 171 publications

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Conductive Polymer Composites from Renewable Resources: An Overview of Preparation, Properties, and Applications

Application of Biodegradable and Biocompatible Nanocomposites in Electronics: Current Status and Future Directions

Contact Info

Product

Resources

About