Microenvironmental interactions of oligodendroglial cells

Yalçın, Belgin; Monje, Michelle

doi:10.1016/j.devcel.2021.06.006

Cited by 19 publications

(7 citation statements)

References 105 publications

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“…In addition to electrical activity, developmental myelination depends on the crosstalk with other glial cells, astrocytes ( Dutta et al, 2019 ; Yalcin and Monje, 2021 ) and particularly microglial cells ( Santos and Fields, 2021 ). Chmr1, the receptor mediating clemastine-effect in OLs, is also expressed in microglia, as reported from previous RNAseq analysis ( Figure 5A ; Zhang et al, 2014 ).…”

Section: Resultsmentioning

confidence: 99%

Clemastine Induces an Impairment in Developmental Myelination

Palma

Chara

Montilla

et al. 2022

Front. Cell Dev. Biol.

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Abnormalities in myelination are associated to behavioral and cognitive dysfunction in neurodevelopmental psychiatric disorders. Thus, therapies to promote or accelerate myelination could potentially ameliorate symptoms in autism. Clemastine, a histamine H1 antagonist with anticholinergic properties against muscarinic M1 receptor, is the most promising drug with promyelinating properties. Clemastine penetrates the blood brain barrier efficiently and promotes remyelination in different animal models of neurodegeneration including multiple sclerosis, ischemia and Alzheimer’s disease. However, its role in myelination during development is unknown. We showed that clemastine treatment during development increased oligodendrocyte differentiation in both white and gray matter. However, despite the increase in the number of oligodendrocytes, conduction velocity of myelinated fibers of corpus callosum decreased in clemastine treated mice. Confocal and electron microscopy showed a reduction in the number of myelinated axons and nodes of Ranvier and a reduction of myelin thickness in corpus callosum. To understand the mechanisms leading to myelin formation impairment in the presence of an excess of myelinating oligodendrocytes, we focused on microglial cells that also express muscarinic M1 receptors. Importantly, the population of CD11c+ microglia cells, necessary for myelination, as well as the levels of insulin growth factor-1 decrease in clemastine-treated mice. Altogether, these data suggest that clemastine impact on myelin development is more complex than previously thought and could be dependent on microglia-oligodendrocyte crosstalk. Further studies are needed to clarify the role of microglia cells on developmental myelination.

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Section: Resultsmentioning

confidence: 99%

Clemastine Induces an Impairment in Developmental Myelination

Palma

Chara

Montilla

et al. 2022

Front. Cell Dev. Biol.

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“…Recent work has shown that oligodendrocytes are of paramount importance in brain functions ( De Faria et al. 2021 ; Yalçın and Monje 2021 ; Munyeshyaka and Fields 2022 ). We consider it highly likely that future work on these cells will lead to important findings on the roles of oligodendrocytic NKCC1 in CNS development, plasticity, and disease (see also Castelijns et al.…”

Section: Discussionmentioning

confidence: 99%

Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development

et al. 2022

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The Na-K-2Cl cotransporter NKCC1 is widely expressed in cells within and outside the brain. However, our understanding of its roles in brain functions throughout development, as well as in neuropsychiatric and neurological disorders, has been severely hindered by the lack of reliable data on its developmental and (sub)cellular expression patterns. We provide here the first properly controlled analysis of NKCC1 protein expression in various cell types of the mouse brain using custom-made antibodies and an NKCC1 knock-out validated immunohistochemical procedure, with parallel data based on advanced mRNA approaches. NKCC1 protein and mRNA are expressed at remarkably high levels in oligodendrocytes. In immature neurons, NKCC1 protein was located in the somata, whereas in adult neurons, only NKCC1 mRNA could be clearly detected. NKCC1 immunoreactivity is also seen in microglia, astrocytes, developing pericytes, and in progenitor cells of the dentate gyrus. Finally, a differential expression of NKCC1 splice variants was observed, with NKCC1a predominating in non-neuronal cells and NKCC1b in neurons. Taken together, our data provide a cellular basis for understanding NKCC1 functions in the brain and enable the identification of major limitations and promises in the development of neuron-targeting NKCC1-blockers.

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“…In addition to OLs, the balance of a healthy glial cell population is crucial to myelin development, homeostasis, and plasticity. 4,32 A certain subset of microglia populating axon tracts promotes myelination during brain development. Astrocytes influence myelin thickness and nodal gap length via thrombin protease secretion.…”

Section: Myelination and Glial Cell-mediated Phagocytosis In Developm...mentioning

confidence: 99%

The roles of microglia and astrocytes in myelin phagocytosis in the central nervous system

Liu

Deng

et al. 2022

J Cereb Blood Flow Metab

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Myelination is an important process in the central nervous system (CNS). Oligodendrocytes (OLs) extend multiple layers to densely sheath on axons, composing the myelin to achieve efficient electrical signal conduction. The myelination during developmental stage maintains a balanced state. However, numerous CNS diseases including neurodegenerative and cerebrovascular diseases cause demyelination and disrupt the homeostasis, resulting in inflammation and white matter deficits. Effective clearance of myelin debris is needed in the region of demyelination, which is a key step for remyelination and tissue regeneration. Microglia and astrocytes are the major resident phagocytic cells in the brain, which may play different or collaborative roles in myelination. Microglia and astrocytes participate in developmental myelination through engulfing excessive unneeded myelin. They are also involved in the clearance of degenerated myelin debris for accelerating remyelination, or engulfing healthy myelin sheath for inhibiting remyelination. This review focuses on the roles of microglia and astrocytes in phagocytosing myelin in the developmental brain and diseased brain. In addition, the interaction between microglia and astrocytes to mediate myelin engulfment is also summarized.

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Microenvironmental interactions of oligodendroglial cells

Cited by 19 publications

References 105 publications

Clemastine Induces an Impairment in Developmental Myelination

Clemastine Induces an Impairment in Developmental Myelination

Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development

The roles of microglia and astrocytes in myelin phagocytosis in the central nervous system

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