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citations
Cited by 49 publications
(80 citation statements)
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References 51 publications
(80 reference statements)
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“…As cabeças polares do tensoativo, na presença de aumento de fase aquosa estariam sendo hidratadas pela água devido à alta hidrofilia desses grupos, promovendo organizações mais rígidas e mais complexas, típicas de fase hexagonal. 36,37 Na Figura 7 também foi possível observar, sob luz polarizada, a presença de "cruzes de malta", sugerindo a presença de fase líquido-cristalina do tipo lamelar. Quando o sistema foi mantido em estufa a 37 ± 2 °C por 15 dias (Figura 6S) observou-se a presença de "estrias", o que sugere o aparecimento de fase líquido-cristalina hexagonal.…”
Section: Microscopia De Luz Polarizadaunclassified
“…This state is called mesophase: the prefix "meso-" means "intermediate". 178 LCs are divided into two categories: thermotropics, which are structured by means of temperature, and lyotropics, which occur by association with amphipathic compounds and solvents. The mesophase lyotropics are mostly lamellar, hexagonal, or cubic, 179 as shown in Figure 4.…”
Section: Liquid Crystalsmentioning
confidence: 99%
“…179,182,183 The LC systems significantly change the drug release profile and reduce the toxicity of drugs, improving clinical efficiency. 178 Hosmer et al in 2012, studied mesophase lamellar LCs formed with glycerides for the incorporation of the anticancer drug paclitaxel. 184 Paclitaxel is highly effective against various types of cancer, including oral cancer; [185][186][187] however, it has severe adverse effects associated with systemic drug administration, including hypersensitivity reactions, thrombocytopenia, and neutropenia.…”
Section: Liquid Crystalsmentioning
confidence: 99%
“…They also offer some protection against photo-or thermal degradation and can promote increased water retention in the stratum corneum, providing increased skin hydration. Finally, LCSs promote the sustained release of active substances and physicochemical stability of emulsions (Formariz et al, 2005;Santos, Rocha Filho, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…They also offer some protection against photo-or thermal degradation and can promote increased water retention in the stratum corneum, providing increased skin hydration. Finally, LCSs promote the sustained release of active substances and physicochemical stability of emulsions (Formariz et al, 2005;Santos, Rocha Filho, 2007).Liquid crystals are not generally employed in formulations of microbiological preservatives because they have large amounts of surfactants that suppress the growth of micro-organisms. Moreover, the high concentration of oil limits water access, which is one of the main causes of antimicrobial action (Oliveira et al, 2007).…”
mentioning
confidence: 99%