Microcytotoxicity and serum blocking factors in malignant melanoma and halo nevus

Roenigk, H. H.

doi:10.1001/archderm.111.6.720

Cited by 11 publications

(1 citation statement)

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“…Immunologic factors may al.so play a role in pigmentary regression of halo nevi (4). Circulating antibodies against a cy-toplasmic antigen have been described in patients with halo nevi (5).…”

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Characterization of the mononuclear infiltrate involved in regression of halo nevi

Akasu¹,

From²,

Kahn³

1994

J Cutan Pathol

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Halo nevi are characterized by progressive degeneration of nevus cells surrounded by a mononuclear cell infiltrate. We studied the morphological features of the nevus cells and the composition of the mononuclear cell infiltrate in 15 cases of halo nevi using immunohistochemical techniques and a battery of antibodies to different subsets of lymphocytes and histiocytes. Regression could be divided into four more or less identifiable stages, associated with different subsets of lymphocytes and monocyte-macrophage lineage cells. Stage I (preregression): nests of unremarkable nevus cells were surrounded by a moderate number of T lymphocytes (relatively small percentage of helper inducer T cells), occasional B cells and macrophages. Stage II (early regression): large number of T lymphocytes and FXIIIa-positive cells were in close contact with nevus cell clusters which showed ragged edges. Lysozyme-positive cells and epidermal Langerhans cells were mildly increased. Stage III (late regression): single nevomelanocytes showing mild atypia were present. Numerous T lymphocytes and macrophages positive for lysozyme, KP1 and/or FXIIIa were interspersed between the nevus cells. Increased numbers of epidermal Langerhans cells were present. Stage IV (complete regression): no nevus cells were observed and moderate numbers of T lymphocytes only remained. These results suggest that T cells, especially T-suppressor cells, and different subsets of macrophages participate in the regression of the nevi.

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confidence: 99%