Microbubbles used for Drug Delivery System

Heer, Hemraj; Kaur, Vishav Prabhjot; Rathor, Sandeep; Aamir, Sheikh; Singh, Charan

doi:10.1002/9781119711698.ch6

Cited by 2 publications

(3 citation statements)

References 44 publications

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“…In recent years, several biocompatible phase-transition nanodroplets composed of organic and/or inorganic materials have been developed for drug delivery systems and photoacoustic tomography ( Awad et al, 2021 ; Heer et al, 2021 ; Zhao et al, 2022 ). However, few studies have discussed the feasibility of block, graft and block-graft copolymers used to prepare phase-transition copolymer nanodroplets as MBs, and compared their ultrasonic enhancement performance in vitro and in vivo .…”

Section: Discussionmentioning

confidence: 99%

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

et al. 2022

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Background: Lipid and polymer microbubbles (MBs) are widely used as ultrasound contrast agents in clinical diagnosis, and possess great potential in ultrasound-mediated therapy due to their drug loading function. However, overcoming the limitations of stability and echo enhancement of MBs are still a considerable challenge.Methods: A series novel block, graft and block-graft copolymers was proposed and prepared in this work, and these copolymers were used as shells to encapsulate perfluoropentane as ultrasound contrast agents. First, block, graft and block-graft copolymers with different topological structures were prepared. Then, these copolymers were prepared into block copolymer phase-transition MBs, graft copolymer phase-transition MBs, and block-graft copolymer phase-transition MBs, respectively. Finally, the dexamethasone was used for drug-loaded phase-transition microbubbles model to explore the potential of theranostic microbubbles.Results: Finally, these three resulting copolymer MBs with average size of 4–5 μm exhibited well enhancement of ultrasound imaging under the influence of different frequencies and mechanical index, and they exhibited a longer contrast-enhanced ultrasound imaging time and higher resistance to mechanical index compared with SonoVue in vitro and in vivo. In vitro drug release results also showed that these copolymer MBs could encapsulate dexamethasone drugs, and the drug release could be enhanced by ultrasonic triggering. These copolymer MBs were therapeutic MBs for targeted triggering drug release.Conclusion: Therefore, the feasibility of block, graft, and block-graft copolymers as ultrasonic contrast agents was verified, and their ultrasonic enhancement performance in vitro and in vivo was compared. The ultrasound contrast agents developed in this work have excellent development potential in comprehensive diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

et al. 2022

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“…119 The first-generation microbubbles, like Albunex, were filled with air, which did not persist in the bloodstream because air dissolves quickly in the blood. 120 These early microbubbles had a thin protein shell that was not very effective at keeping the air inside. To improve microbubble stability, second and third-generation contrast agents were incorporated with gases like perfluorocarbons or sulfur hexafluoride.…”

Section: Polyethylenimine (Pei)mentioning

confidence: 99%

“…The first-generation microbubbles, like Albunex, were filled with air, which did not persist in the bloodstream because air dissolves quickly in the blood . These early microbubbles had a thin protein shell that was not very effective at keeping the air inside.…”

Section: Bioinspired Polymers For Gene Deliverymentioning

confidence: 99%

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

Kumar,

Karim,

Sweety

et al. 2023

ACS Appl. Bio Mater.

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Disorders of the central nervous system (CNS) which include a wide range of neurodegenerative and neurological conditions have become a serious global issue. The presence of CNS barriers poses a significant challenge to the progress of designing effective therapeutic delivery systems, limiting the effectiveness of drugs, genes, and other therapeutic agents. Natural nanocarriers present in biological systems have inspired researchers to design unique delivery systems through biomimicry. As natural resource derived delivery systems are more biocompatible, current research has been focused on the development of delivery systems inspired by bacteria, viruses, fungi, and mammalian cells. Despite their structural potential and extensive physiological function, making them an excellent choice for biomaterial engineering, the delivery of nucleic acids remains challenging due to their instability in biological systems. Similarly, the efficient delivery of genetic material within the tissues of interest remains a hurdle due to a lack of selectivity and targeting ability. Considering that gene therapies are the holy grail for intervention in diseases, including neurodegenerative disorders such as Alzheimer's disease, Parkinson's Disease, and Huntington's disease, this review centers around recent advances in bioinspired approaches to gene delivery for the prevention of CNS disorders.

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Microbubbles used for Drug Delivery System

Cited by 2 publications

References 44 publications

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

Phospholipid-mimicking block, graft, and block-graft copolymers for phase-transition microbubbles as ultrasound contrast agents

Bioinspired Approaches for Central Nervous System Targeted Gene Delivery

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