2017
DOI: 10.1016/j.ebiom.2017.09.020
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Abstract: Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental conditions worldwide. There is growing awareness that ASD is highly comorbid with gastrointestinal distress and altered intestinal microbiome, and that host-microbiome interactions may contribute to the disease symptoms. However, the paucity of knowledge on gut-brain axis signaling in autism constitutes an obstacle to the development of precision microbiota-based therapeutics in ASD. To this end, we explored the interactions between… Show more

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Cited by 267 publications
(243 citation statements)
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References 75 publications
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“…Surprisingly, stress induced an increased gene expression of tight junction proteins Cldn1 and Tjp1, even though increased intestinal permeability doesn't necessarily correlate to decreased tight junction gene expression (Golubeva et al . ). In addition, no differences were seen in plasma LBP levels, an indirect marker of systemic exposure to the intestinal bacterial product lipopolysaccharide.…”
Section: Discussionmentioning
confidence: 97%
“…Surprisingly, stress induced an increased gene expression of tight junction proteins Cldn1 and Tjp1, even though increased intestinal permeability doesn't necessarily correlate to decreased tight junction gene expression (Golubeva et al . ). In addition, no differences were seen in plasma LBP levels, an indirect marker of systemic exposure to the intestinal bacterial product lipopolysaccharide.…”
Section: Discussionmentioning
confidence: 97%
“…[10,76] Similarly, alterations in the microbiota in a murine model of autism are associated with deficient tryptophan metabolism and gastrointestinal dysfunction. [77] Prebiotic and probiotic treatments have been shown to alter central levels of serotonin or serotonin receptors in the hippocampus and prefrontal cortex, both regions that are highly connected to the amygdala. [11,73] This could have an important influence on the amygdala, where serotonin signaling regulates activity and synaptic plasticity, guiding the structure's response to emotional stimuli.…”
Section: Microbiota Regulates Tryptophan Metabolismmentioning
confidence: 99%
“…In an ASD mouse model (maternal immune activation (MIA) model), in which atypical social behaviors were induced by exposing the mother to a virus, the administration of the probiotic Bacteroides fragilis resulted in a reduction of some of the observed behavioral abnormalities and reduced gut permeability [38]. Golubeva et al [39] explored the interactions between gut microbiota, gut physiology, and social behavior in a BTBR T þ Itpr3 tf /J mouse model of ASD. A reduction in the relative abundance of bile acid-metabolizing Bifidobacterium and Blautia species was observed in the BTBR gut.…”
Section: Introductionmentioning
confidence: 99%