Microbiota dysbiosis in odontogenic rhinosinusitis and its association with anaerobic bacteria

Lu, Yen‐Ting; Wang, Shao–Hung; Liou, Ming-Li; Lee, Cheng-Yang; Li, Yuxuan; Lu, Ying‐Chou; Hsin, Chung‐Han; Yang, Shun‐Fa; Chen, Yih-Yuan; Chang, Tzu-Hao

doi:10.1038/s41598-022-24921-z

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Literature findings highlight the prevalence of anaerobes, specifically Porphyromonas, Peptostreptococcus, Prevotella, and Fusobacterium, among the bacteria involved in the physiopathology of odontogenic sinusitis. However, aerobes of both Gram-positive and Gram-negative types can also be found in the cultures [ 37 ]. Odontogenic rhinosinusitis is thought to be a polymicrobial infection that primarily consists of anaerobes and gathers germs from the respiratory system and mouth cavity [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Management of oculo-orbital complications of odontogenic sinusitis in adults

2024

RJO

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Introduction: Odontogenic maxillary sinusitis (OMS) is an infectious inflammatory pathology caused by a dental condition. Considering the anatomical relations with the orbit, maxillary sinus infection can easily spread, evolving into severe oculo-orbital complications that can sometimes be life-threatening. Material and methods: We performed a retrospective study of over 2 years, examining the data of 18 patients diagnosed with OMS with oculo-orbital complications. The patients were evaluated regarding their dental history, symptoms, clinical and endoscopic findings, ophthalmologic evaluation, bacteriologic tests, computed tomography (CT) imaging, medical and surgical treatment, and outcomes. Results: The age of the patients was between 24 and 65 years old with an almost equal gender distribution: 10 female and 8 male patients. From the total, 7 patients had type II diabetes, 2 of whom were insulin-dependent, 1 patient had thrombophilia and 2 patients had renal failure with peritoneal dialysis. Regarding the type of oculo-orbital complications, 10 patients were diagnosed with preseptal cellulitis and 8 with orbital cellulitis. Just 5 patients with orbital cellulitis required surgical treatment and orbitotomy was performed, followed by endonasal endoscopic drainage. The evolution after surgical treatment was favorable for all operated patients. Discussions: Oculo-orbital complications of OMS are typically more severe than those of rhinogenic sinusitis because anaerobic bacteria are involved. Immunosuppression represents a favorable environment for the development of OMS and its complications, diabetes being the most common risk factor. A negative prognostic feature is the appearance of ophthalmological symptoms in both eyes, so visual function may be reduced. The treatment of oculo-orbital complications of OMS is urgent and depends on a broad-spectrum antibiotic therapy associated or not with surgical intervention. Conclusions: The diagnosis of oculo-orbital complications of OMS is complex and requires clinical experience as well as extensive medical knowledge to treat both the cause and the consequences of the conditions quickly and effectively. The proper management of oculo-orbital complications is based on a multidisciplinary team: ophthalmology, ENT, dentistry, imaging, and laboratory. Abbreviations: OMS = odontogenic maxillary sinusitis, CT = computed tomography, ENT = ear-nose-throat, MRI = magnetic resonance imaging, HNS = head and neck surgery

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Section: Discussionmentioning

confidence: 99%

Management of oculo-orbital complications of odontogenic sinusitis in adults

2024

RJO

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“…Regarding the bacteria implicated in the physiopathology of odontogenic sinusitis, literature data underline that anaerobes are prevalent, particularly Porphyromonas, Peptostreptococcus, Prevotella, and Fusobacterium, but we can also find Gram-positive and Gram-negative aerobes in the cultures [ 12 ]. It is considered that odontogenic rhinosinusitis is a polymicrobial infection gathering bacteria from the oral cavity and from the respiratory tract with a predominance of anaerobes [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Oculo-orbital complications of odontogenic sinusitis

2023

rjo

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Introduction: Odontogenic sinusitis is a well-known, but under-studied bacterial infection of the maxillary sinus that can extend to other sinuses, the orbit, or even the endocranium. Material and methods: We performed an observational retrospective study on the patients with odontogenic sinusitis treated in our hospital over a five-year period. We included patients over 18 years old diagnosed with odontogenic sinusitis and ocular complications and we excluded patients with ocular complications nonrelated to dental-originated sinusitis or patients with odontogenic sinusitis without orbital-ocular complications. Results: We examined the charts of 46 patients. From the total number of patients with oculo-orbital complications generated by odontogenic sinusitis, only 7 were women. The mean age was 33,7 with a standard deviation of 15,7 years. The oculo-orbital complications were assessed according to the Chandler classification. The most frequent orbital complication was preseptal cellulitis followed by orbital cellulitis. All the patients were treated with antibiotic covering both anaerobic and aerobic bacteria and 40 of the patients in our study received surgical treatment. The outcomes were favorable for all the patients in our study with clinical resolution. Conclusion: The oculo-orbital complications of odontogenic sinusitis are severe because they can result in vision loss or other ocular sequelae. The bacteriological features of this sinusitis explain the special characteristics of this infection and can facilitate the extent of the infection to the orbit. Prompt intervention with antibiotics covering anaerobic and aerobic bacteria and surgery addressed to the affected sinus/ sinuses, the dental disease and the orbital pathology ensures a big success rate in the therapy of these complications.

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Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment

Lin,

Wang,

Wang

et al. 2024

Int J Oral Sci

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AbstarctOdontogenic maxillary sinusitis (OMS) is a subtype of maxillary sinusitis (MS). It is actually inflammation of the maxillary sinus that secondary to adjacent infectious maxillary dental lesion. Due to the lack of unique clinical features, OMS is difficult to distinguish from other types of rhinosinusitis. Besides, the characteristic infectious pathogeny of OMS makes it is resistant to conventional therapies of rhinosinusitis. Its current diagnosis and treatment are thus facing great difficulties. The multi-disciplinary cooperation between otolaryngologists and dentists is absolutely urgent to settle these questions and to acquire standardized diagnostic and treatment regimen for OMS. However, this disease has actually received little attention and has been underrepresented by relatively low publication volume and quality. Based on systematically reviewed literature and practical experiences of expert members, our consensus focuses on characteristics, symptoms, classification and diagnosis of OMS, and further put forward multi-disciplinary treatment decisions for OMS, as well as the common treatment complications and relative managements. This consensus aims to increase attention to OMS, and optimize the clinical diagnosis and decision-making of OMS, which finally provides evidence-based options for OMS clinical management.

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Microbiota dysbiosis in odontogenic rhinosinusitis and its association with anaerobic bacteria

Cited by 4 publications

References 40 publications

Management of oculo-orbital complications of odontogenic sinusitis in adults

Management of oculo-orbital complications of odontogenic sinusitis in adults

Oculo-orbital complications of odontogenic sinusitis

Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment

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