2015
DOI: 10.1016/j.cmet.2015.09.028
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Abstract: SUMMARY The gut microbiota plays a key role in host metabolism. Toll-Like Receptor 5 (TLR5), a flagellin receptor, is required for gut microbiota homeostasis. Accordingly, TLR5 deficient (T5KO) mice are prone to develop microbiota-dependent metabolic syndrome. Here we observed that T5KO mice display elevated neutral lipids with a compositional increase of oleate [C18:1 (n9)] relative to wild-type littermates. Increased oleate contribution to hepatic lipids and liver SCD1 expression were both microbiota-depende… Show more

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Cited by 129 publications
(112 citation statements)
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References 54 publications
(74 reference statements)
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“…Despite all that, elevated fecal SCFA is positively associated with metabolic syndrome in humans [23,24]. Similarly, we demonstrated that uncontrolled prolonged generation of SCFA by dysbiotic microbiota promotes metabolic syndrome in TLR5-KO mice [18]. These observations are further supported by a recent study which demonstrates the positive correlation between obesity and the augmented abundance of propionate/acetate producers Phascolarctobacterium, Proteus mirabilis and Veillonellaceae in high fat diet-fed rats [25].…”
Section: The Triad Of Gut Microbiota Metabolic Syndrome and Cardiovasupporting
confidence: 75%
See 1 more Smart Citation
“…Despite all that, elevated fecal SCFA is positively associated with metabolic syndrome in humans [23,24]. Similarly, we demonstrated that uncontrolled prolonged generation of SCFA by dysbiotic microbiota promotes metabolic syndrome in TLR5-KO mice [18]. These observations are further supported by a recent study which demonstrates the positive correlation between obesity and the augmented abundance of propionate/acetate producers Phascolarctobacterium, Proteus mirabilis and Veillonellaceae in high fat diet-fed rats [25].…”
Section: The Triad Of Gut Microbiota Metabolic Syndrome and Cardiovasupporting
confidence: 75%
“…Our group have demonstrated that gut dysbiosis induces hyperphagia that culminates in the development of metabolic syndrome in mice lacking the toll-like receptor 5 (TLR5-KO) [18]. The increased mucosal translocation of bacterial LPS in mice supports the hypothesis that metabolic endotoxemia eventuate metabolic syndrome [19].…”
Section: The Triad Of Gut Microbiota Metabolic Syndrome and Cardiovamentioning
confidence: 99%
“…In a cross-sectional study of 4,677 adults, Hosseinpour-Niazi et al [41] showed that increased SFA intakes were positively associated with the prevalence of MS, independently of total dietary fat. It has been suggested that augmented alimentary short-chain fatty acids in an animal model could promote conversion of SFA to oleate and thus to be a player in MS development [42]. …”
Section: Discussionmentioning
confidence: 99%
“…This is evident given that hepatic SCD1 deficiency protects against HCD induced obesity and improves insulin sensitivity [30, 31]. Similarly, hepatic SCD1 deficiency attenuated short chain FA mediated hepatic steatosis and insulin resistance in Toll-like receptor 5 knockout mouse model [37]. …”
Section: Scd1 In Liver Metabolismmentioning
confidence: 99%