Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress

Vodička, Martin; Ergang, Peter; Hrnčíř, Tomáš; Mikulecká, Anna; Kvapilová, Pavlína; Vagnerová, Karla; Šestáková, Blanka; Fajstová, Alena; Hermanová, Petra; Hudcovic, Tomáš; Kozáková, Hana; Pácha, Jiřı́

doi:10.1016/j.bbi.2018.07.007

Cited by 76 publications

(52 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…During chronic psychological stress responses, the hypothalamus-pituitaryadrenal (HPA) axis is activated through the secretion of corticotropin-releasing hormone (CRH) and vasopressin from t h e h y p o t h a l a m u s . T h e s u b s e q u e n t r e l e a s e o f adrenocorticotropin (ACTH) hormone from the pituitary gland initiates glucocorticoid secretion from the adrenal cortex (30). The major glucocorticoid is cortisol in humans and CORT in rodents.…”

Section: Discussionmentioning

confidence: 99%

Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

Zhan

Zhou

et al. 2020

Front. Psychiatry

View full text Add to dashboard Cite

Background: Cognitive impairment is a complication of type 2 diabetes mellitus (T2DM) that affects the central nervous system (CNS). Studies have shown that chronic psychological stress may promote the development of T2DM into diabetes-associated cognitive decline (DACD). Previously, cognitive impairment in T2DM was correlated predominantly with insulin resistance in the medial prefrontal cortex (mPFC). Aims:We examined the effect of the ZiBuPiYin recipe (ZBPYR) on Zucker diabetic fatty (ZDF) rats and explored the impact of chronic stress on altered b-amyloid (Ab) metabolism through insulin receptor substrate (IRS) 1/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway after the induction of chronic psychological stress.Main Methods: After chronic psychological stress and drug treatment, cognitive function was observed via behavioral experiments. The activation of the hypothalamus-pituitaryadrenal (HPA) axis and levels of Ab were detected by enzyme-linked immunosorbent assay, and the expression of related proteins was evaluated by Western blotting.Key Findings: ZBPYR treatment significantly decreased anxious-like behaviors and plasma corticosterone (CORT) levels, and ameliorated learning and memory impairments of ZDF rats after chronic psychological stress. ZBPYR also reduced the deposition of Ab in the mPFC, improved brain insulin resistance, and modulated the mTOR-autophagy pathway.Significance: ZBPYR may be a potential therapeutic application for the treatment of DACD induced by chronic psychological stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

Zhan

Zhou

et al. 2020

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Further, they can act on tumor and stromal cells in the tumor microenvironment to promote tumor growth, invasion, and metastasis. In addition to these pathways, emerging trends include investigation of the correlation between chronic stress and the microbiota-gut-brain axis (61)(62)(63), and its impact on intestinal diseases (64). The effects of daily stress on the neuroendocrine and immune function of healthy human individuals, which may be modulated by the individual's personality, have been confirmed, for example, by Biondi et al (65).…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 98%

Chronic Stress Promotes Cancer Development

et al. 2020

View full text Add to dashboard Cite

Stress is an inevitable part of life. Chronic stress on account of reasons like adversity, depression, anxiety, or loneliness/social isolation can endanger human health. Recent studies have shown that chronic stress can induce tumorigenesis and promote cancer development. This review describes the latest progress of research on the molecular mechanisms by which chronic stress promotes cancer development. Primarily, chronic stress activates the classic neuroendocrine system [the hypothalamic-pituitary-adrenal (HPA) axis] and the sympathetic nervous system (SNS) and leads to a decline and dysfunction of the prefrontal cortex and the hippocampus under stress. Stress hormones produced during the activation of both the HPA axis and the SNS can promote tumorigenesis and cancer development through a variety of mechanisms. Chronic stress can also cause corresponding changes in the body's immune function and inflammatory response, which is significant because a long-term inflammatory response and the decline of the body's immune surveillance capabilities are implicated in tumorigenesis. Stress management is essential for both healthy people and cancer patients. Whether drugs that limit the signaling pathways downstream of the HPA axis or the SNS can suppress chronic stress-induced cancers or prolong patient survival deserves further study.

show abstract

“…However, the overall relationship between stress response, cortisol and the microbiome is complex. The microbiome may be influenced by other stress hormones, by interactions amongst microbes or with the host immune system, while microbiota and/or their metabolites are also well known to influence host stress response signalling (Burokas et al 2017; de Weerth 2017; Simard et al 2014; Vodicka et al 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, while host stress response influences the microbiome, the microbiome can also influence host stress response. Microbiota and their metabolites are known to exert effects throughout the mammalian hypothalamus-pituitary-adrenal (HPA) axis, influencing glucocorticoid synthesis, release and signalling pathways (Burokas et al 2017; de Weerth 2017; Simard et al 2014; Vodicka et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Cortisol-induced signatures of stress in the fish microbiome

Webster

Rodríguez‐Barreto

Consuegra

et al. 2019

Preprint

View full text Add to dashboard Cite

Stress experienced in intensive aquaculture can compromise fish growth, condition and immunity. Microbiome disruption may contribute to these adverse health effects, but little is known about how stress affects fish microbial communities. Here, we specifically examined the effects of stress-induced cortisol production on the fish microbiome. We exposed juvenile Atlantic salmon to a mild confinement stressor for two weeks. We then measured cortisol in the plasma, skin-mucus and faeces, and characterised the skin and faecal microbiome. Faecal and skin cortisol concentrations increased in fish exposed to confinement stress, and were positively correlated with plasma cortisol. Elevated faecal cortisol was associated with pronounced changes in the diversity and structure of the faecal microbiome. In particular, we identified a marked decline in probiotic Lactobacillales (Carnobacterium sp.) and an increase in pro-inflammatory and pathogenic taxa within the classes Clostridia and Gammaproteobacteria. In contrast, skin-mucus cortisol concentrations were lower and not associated with any detectable changes in the skin microbiome. Our results demonstrate that cortisol disrupts the gut microbiome, which may, in turn, contribute to the adverse effects of stress on fish health. They also highlight the value of using non-invasive faecal samples to monitor stress, including simultaneous determination of cortisol and stress-responsive bacteria.

show abstract

Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress

Cited by 76 publications

References 39 publications

Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

Effect of the ZiBuPiYin Recipe on Diabetes-Associated Cognitive Decline in Zucker Diabetic Fatty Rats After Chronic Psychological Stress

Chronic Stress Promotes Cancer Development

Cortisol-induced signatures of stress in the fish microbiome

Contact Info

Product

Resources

About