2019
DOI: 10.3390/cells8040293
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Abstract: Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant composition of the microbiome, characterizes breast cancer. In this review we discuss the changes to the metabolism of breast cancer cells, as well as the composition of the breast and gut microbiome in breast cancer. The role of the breast microbiome in breast cancer is unresolved, nevertheless it seems that the gut microbiome does have a role in the pathology of the disease. The gut microbiome secretes bioactive metabolit… Show more

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Cited by 129 publications
(191 citation statements)
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References 273 publications
(401 reference statements)
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“…The finding that perturbation in the gut microbiome can affect tumor dissemination at a distant site supports the notion that the gut microbiome can be considered as an endocrine gland (3,5). A number of metabolites associated with activity of gut bacterial species can travel through the blood and have been shown in vitro to affect breast cancer cell and immune cell function.…”
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confidence: 54%
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“…The finding that perturbation in the gut microbiome can affect tumor dissemination at a distant site supports the notion that the gut microbiome can be considered as an endocrine gland (3,5). A number of metabolites associated with activity of gut bacterial species can travel through the blood and have been shown in vitro to affect breast cancer cell and immune cell function.…”
mentioning
confidence: 54%
“…Emerging evidence over the past 10 years, enabled by new technologies such as next-generation sequencing, has also suggested the influence of the gut microbiome on health and disease extends beyond the gastrointestinal tract (2). Of significance, a number of observational and in vitro studies suggest relationships between the gut microbiome and breast cancer (3). While these studies are intriguing, a functional relationship between the gut microbiome and breast cancer has yet to be demonstrated until recently.…”
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confidence: 99%
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“…Schlüsselrollen im Glukose-und Fettstoffwechsel spielen dabei als Bindungsstellen der GS v. a. die Transkriptionsfaktoren FXR (Farnesoid-X-Receptor), der in solchen Geweben exprimiert wird, die mit GS in Kontakt kommen, und LXR (Liver-X-Receptor), der in der Leber ausgebildet wird [11] [22] und können auf diesem Weg in die Entwicklung einer nicht-alkoholischen Fettleber eingreifen [3]. Es gibt darüber hinaus auch deutliche Zusammenhänge von Veränderungen in der GS-Homöostase mit Darmkrebs (v. a. Desoxycholsäure) [9], dem Nichtkleinzelligen Lungen-Ca (alle sekundären GS) [8] und Brustkrebs (v. a. Lithocholsäure) [2,13]. Die Korrelationen zwischen dem Auftreten dieser Erkrankungen und bestimmten Dysbiosen des intestinalen Mikrobioms leiteten darauf hin, dass, wie man inzwischen weiß, der Hintergrund eine bakterielle Umsetzung der GS ist:…”
Section: Merkeunclassified
“…It is known that the state of tumor cell biological membrane and its fatty acid composition potentiate the main elements of carcinogenesis. [2][3][4][5].…”
Section: Introductionmentioning
confidence: 99%