Microbiome-metabolomic analysis of the impact of Zizyphus jujuba cv. Muzao polysaccharides consumption on colorectal cancer mice fecal microbiota and metabolites

Ji, Xiaolong; Hou, Chunyan; Zhang, Xuelian; Han, Lin; Su, Yin; Peng, Qiang; Wang, Min

doi:10.1016/j.ijbiomac.2019.03.175

Cited by 53 publications

(20 citation statements)

References 42 publications

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“…Some Bacteroides spp., such as Bacteroides fragilis , are found prevalent in multiple sample types of maternal and neonatal microbiota in human, reflecting their possible significance to GDM response across generations and body sites . The ability of these bacteria to use complex glycans significantly contributes to their great abundance in the gastrointestinal tract . A recent study has shown that an extensive enzymatic apparatus encoded by multiple co‐regulated genetic loci in the Bacteroides genome is involved in the metabolism of complex N‐glycans .…”

Section: Discussionmentioning

confidence: 99%

“…12 The ability of these bacteria to use complex glycans significantly contributes to their great abundance in the gastrointestinal tract. 46 A recent study has shown that an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci in the Bacteroides genome is involved in the metabolism of complex N-glycans. 14 Therefore, the large amounts of fucosylated and sialylated N-glycans may have provided a major carbon source for Bacteroides spp., resulting in their predominance in the gut of GDM-fed neonates.…”

Section: Discussionmentioning

confidence: 99%

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High levels of fucosylation and sialylation of milk N‐glycans from mothers with gestational diabetes mellitus alter the offspring gut microbiome and immune balance in mice

et al. 2020

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Gestational diabetes mellitus (GDM) is significantly associated with allergen sensitization in early childhood, and this may influence the gut microbiome and immune system of the children. In addition to mother‐to‐child transmission of microbes, milk glycans play a pivotal role in shaping the gut microbiome of infants. A previous study has demonstrated alterations in the major milk N‐glycans of mothers with GDM. However, the impact of these changes on the gut microbiome and immune response of the neonates has yet to be studied. Here, we aimed to compare the glycosylation levels of various milk glycans between normal and GDM mice, and to characterize the intestinal microbiome and immune responses of the offspring after weaning. We found that GDM mouse milk contained significantly higher concentrations of fucosylated and sialylated N‐glycans than control mice, but there was no difference in the concentration of milk oligosaccharides between the groups. The differences in milk N‐glycans had direct effects on the intestinal microbiome of the offspring, which in turn affected their immune response upon challenge with ovalbumin (OVA), with disruptions in the Th1/Th2 and Th17/Treg cell balances. This study lays the foundation for further research and development of specific nutritional care for the offspring of GDM mothers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

High levels of fucosylation and sialylation of milk N‐glycans from mothers with gestational diabetes mellitus alter the offspring gut microbiome and immune balance in mice

et al. 2020

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“…Mice in the sham‐operated control group and experimental group I received an equal volume of normal saline. The ZJP doses were referenced in a previous report (Ji, Hou, et al, 2019) and our pilot experiments. The drug was diluted in normal saline, and a final concentration of 10 mg/ml was obtained.…”

Section: Methodsmentioning

confidence: 99%

“…Many studies have shown that Zizyphus jujuba cv. Muzao polysaccharides (ZJPs) extracted from jujube have many biological activities, such as antioxidant (Chen et al., 2013; Wang, 2011), anticancer (Ji, Hou, et al, 2019; Wu et al., 2019), antibacterial, anti‐inflammatory (Li et al.,2014; Periasamy et al., 2020), hypolipidemic (Ji et al., 2018), immunoregulatory (Chi et al., 2015; Zhang et al., 2017), hepatoprotective (Liu et al., 2015), and enteroprotective (Ji, Hou, et al, 2019; Ji, Zhang, et al, 2019) activities. An analysis showed that monosaccharides included arabinose, galactose, xylose, rhamnose, glucose and mannose, and the molar ratio was 7.8:3.8:2.2:1.2:1.4:0.2 (Jiao et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Zizyphus jujuba cv. Muzao polysaccharides enhance intestinal barrier function and improve the survival of septic mice

Zhou

Guo

et al. 2021

J Food Biochem

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This study aimed to examine the role of Zizyphus jujuba cv. Muzao polysaccharides (ZJPs) in protecting intestinal barrier function and the survival of septic mice. The sepsis mouse model was generated through cecal ligation and puncture (CLP) to observe the effect of ZJPs on the function of the intestinal barrier in the context of sepsis. We observed the clinical symptoms and survival time of the mice and evaluated serum inflammatory cytokines, intestinal pathological changes and intestinal permeability. Moreover, tight junction (TJ) proteins and apoptosis‐associated proteins in intestinal tissue were examined. Finally, TLR4/NF‐κB pathway‐related proteins were measured in all groups. The results showed that pretreatment with ZJPs improved clinical and histological scores and reduced intestinal barrier permeability, and the levels of proinflammatory factors were decreased. Pretreatment with ZJPs also upregulated the levels of TJ proteins and downregulated the expression of proapoptotic proteins. Moreover, the activation of TLR4/NF‐κB signaling was partly inhibited in septic mice by ZJPs pretreatment. The current study provides evidence that ZJPs have the potential to protect intestinal barrier function and improve the survival of septic mice via the attenuation of TLR4/NF‐κB inflammatory signaling. Practical applications This study reports the potential protective effect of ZJPs against cecal ligation and puncture (CLP)‐induced sepsis. Our data reveal that CLP induced damage to the gut mucosal barrier, inflammation, and apoptosis in intestinal tissues. However, pretreatment with ZJPs improved clinical and histological scores, reduced intestinal barrier permeability, and decreased the levels of proinflammatory factors in mice. Pretreatment with ZJPs also upregulated the levels of TJ proteins and downregulated the expression of proapoptotic proteins. Moreover, the activation of TLR4/NF‐κB signaling was partly inhibited in septic mice after ZJPs pretreatment. These findings provide evidence that pretreatment with ZJPs has the potential to attenuate CLP‐induced gut damage in mice by restraining inflammation and apoptosis via the attenuation of NF‐κB signaling. It provides a basis for further study of ZJPs in sepsis.

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“…These results suggest that Zizyphus jujuba cv. Muzao polysaccharides intake by mice model of CRC can inhibit CRC by alternating the gut microbiota composition and changing the fecal‐metabolome profiles such as the production of amino acid and carbohydrate, and increasing the level of SCFAs 33 . It is therefore conceivable that the modulation of gut microbiota with prebiotic supplements could stimulate G‐protein‐coupled receptors and PPAPγ receptors and modify the hormone peptide YY (PYY) as an anticancer hormone in gut.…”

Section: Intervention On Gut Microbiota Composition Using Probiotics Prebiotics and Dietsmentioning

confidence: 99%

Intervention on gut microbiota may change the strategy for management of colorectal cancer

Taghinezhad-S

Mohseni

2021

J of Gastro and Hepatol

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Dysbiosis in the gut microbiota composition due to environmental or genetic variations can disrupt the immune system and may promote several diseases such as colorectal cancer (CRC). Gut microbiota can alter the toxicity and efficiency of an extensive range of CRC treatment methods, especially surgery, chemotherapy, radiotherapy, and immunotherapy. The recent scientific evidence suggested that gut microbiota modulation exhibits an essential positive influence on inhibition and treatment of CRC. The literature survey revealed that modulating the gut microbiota composition by probiotics, prebiotics, and diets protects CRC patients from treatment‐associated adverse effects. This review summarizes the recent advancements in the association between interventions on gut microbiota and CRC to provide innovative strategies for enhancing the safety and efficiency of CRC therapy.

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Microbiome-metabolomic analysis of the impact of Zizyphus jujuba cv. Muzao polysaccharides consumption on colorectal cancer mice fecal microbiota and metabolites

Cited by 53 publications

References 42 publications

High levels of fucosylation and sialylation of milk N‐glycans from mothers with gestational diabetes mellitus alter the offspring gut microbiome and immune balance in mice

High levels of fucosylation and sialylation of milk N‐glycans from mothers with gestational diabetes mellitus alter the offspring gut microbiome and immune balance in mice

Zizyphus jujuba cv. Muzao polysaccharides enhance intestinal barrier function and improve the survival of septic mice

Intervention on gut microbiota may change the strategy for management of colorectal cancer

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