Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?

Ternes, Dominik; Karta, Jessica; Tsenkova, Mina; Wilmes, Paul; Haan, Serge; Letellier, Elisabeth

doi:10.1016/j.tim.2020.01.001

Cited by 161 publications

(181 citation statements)

References 165 publications

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“…Intriguingly, a decreased carriage of Bulleidia was also captured in the oral cavity of patients with esophageal squamous cell carcinoma (Chen et al, 2015). Moreover, some taxa of these genera were found to be enriched in tumor and stool samples of colorectal cancer patients, such as Fusobacterium nucleatum, Parvimonas micra, Porphyromonas asaccharolytica, and Peptostreptococcus stomatis, Prevotella intermedia (Ternes et al, 2020). And we recently found a higher load of Fusobacterium in the gastric mucosa of GC patients compared to SG (Wang et al, 2020).…”

Section: Discussionmentioning

confidence: 89%

Salivary Microbiota for Gastric Cancer Prediction: An Exploratory Study

Huang

Gao

et al. 2021

Front. Cell. Infect. Microbiol.

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To characterize the salivary microbiota in patients at different progressive histological stages of gastric carcinogenesis and identify microbial markers for detecting gastric cancer, two hundred and ninety-three patients were grouped into superficial gastritis (SG; n = 101), atrophic gastritis (AG; n = 93), and gastric cancer (GC; n = 99) according to their histology. 16S rRNA gene sequencing was used to access the salivary microbiota profile. A random forest model was constructed to classify gastric histological types based on the salivary microbiota compositions. A distinct salivary microbiota was observed in patients with GC when comparing with SG and AG, which was featured by an enrichment of putative proinflammatory taxa including Corynebacterium and Streptococcus. Among the significantly decreased oral bacteria in GC patients including Haemophilus, Neisseria, Parvimonas, Peptostreptococcus, Porphyromonas, and Prevotella, Haemophilus, and Neisseria are known to reduce nitrite, which may consequently result in an accumulation of carcinogenic N-nitroso compounds. We found that GC can be distinguished accurately from patients with AG and SG (AUC = 0.91) by the random forest model based on the salivary microbiota profiles, and taxa belonging to unclassified Streptophyta and Streptococcus have potential as diagnostic biomarkers for GC. Remarkable changes in the salivary microbiota functions were also detected across three histological types, and the upregulation in the isoleucine and valine is in line with a higher level of these amino acids in the gastric tumor tissues that reported by other independent studies. Conclusively, bacteria in the oral cavity may contribute gastric cancer and become new diagnostic biomarkers for GC, but further evaluation against independent clinical cohorts is required. The potential mechanisms of salivary microbiota in participating the pathogenesis of GC may include an accumulation of proinflammatory bacteria and a decline in those reducing carcinogenic N-nitroso compounds.

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Section: Discussionmentioning

confidence: 89%

Salivary Microbiota for Gastric Cancer Prediction: An Exploratory Study

Huang

Gao

et al. 2021

Front. Cell. Infect. Microbiol.

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“…CRC patient gut microbiota differs from healthy individuals, highlighting a reduced diversity ( 67 ) at fecal and tumor levels ( 68 ), with the phyla Proteobacteria , Fusobacteria , and Lentisphaerae enrichment in fecal samples, and Firmicutes and Actinobacteria reduced ( 67 ). The bacterial genera Fusobacterium, Peptostreptococcus, Porphyromonas, Prevotella, Parvimonas, Bacteroides , and Gemella , are prominently enriched in CRC ( 69 ) and in contrast, the genera Roseburia, Clostridium, Faecalibacterium and Bifidobacterium decreased ( 68 ).…”

Section: Gut Microbiomementioning

confidence: 99%

“…Bacteria are involved in colorectal carcinogenesis through pathomechanisms such as: tissue invasion, local immune response modulation and metabolites or toxins secretion ( Table 1 ). The most relevant CRC-associated bacteria are Fusobacterium nucleatum, Peptostreptococcus ssp., Porphyromonas ssp., Prevotella intermedia, Parvimonas micra, Bacteroides fragilis and Gemella morbillorum ( 69 ).…”

Section: Gut Microbiomementioning

confidence: 99%

Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment

et al. 2021

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Colorectal cancer (CRC) is one of the most common cancers worldwide. As with other cancers, CRC is a multifactorial disease due to the combined effect of genetic and environmental factors. Most cases are sporadic, but a small proportion is hereditary, estimated at around 5-10%. In both, the tumor interacts with heterogeneous cell populations, such as endothelial, stromal, and immune cells, secreting different signals (cytokines, chemokines or growth factors) to generate a favorable tumor microenvironment for cancer cell invasion and metastasis. There is ample evidence that inflammatory processes have a role in carcinogenesis and tumor progression in CCR. Different profiles of cell activation of the tumor microenvironment can promote pro or anti-tumor pathways; hence they are studied as a key target for the control of cancer progression. Additionally, the intestinal mucosa is in close contact with a microorganism community, including bacteria, bacteriophages, viruses, archaea, and fungi composing the gut microbiota. Aberrant composition of this microbiota, together with alteration in the diet‐derived microbial metabolites content (such as butyrate and polyamines) and environmental compounds has been related to CRC. Some bacteria, such as pks+ Escherichia coli or Fusobacterium nucleatum, are involved in colorectal carcinogenesis through different pathomechanisms including the induction of genetic mutations in epithelial cells and modulation of tumor microenvironment. Epithelial and immune cells from intestinal mucosa have Pattern-recognition receptors and G-protein coupled receptors (receptor of butyrate), suggesting that their activation can be regulated by intestinal microbiota and metabolites. In this review, we discuss how dynamics in the gut microbiota, their metabolites, and tumor microenvironment interplays in sporadic and hereditary CRC, modulating tumor progression.

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“…2020 (Ternes et al, 2020) Changes in gut microbiome can reduce the carcinogenic effect of colitis-related colorectal cancer:…”

Section: Descriptionmentioning

confidence: 99%

Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare

et al. 2020

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Advances in systems biology, particularly based on the omics approaches, have resulted in a paradigm shift in both traditional Chinese medicine (TCM) and the gut microbiome research. In line with this paradigm shift, the importance of TCM and gut microbiome in healthcare, as well as their interplay, has become clearer. Firstly, we briefly summarize the current status of three topics in this review: microbiome, TCM, and relationship of TCM and microbiome. Second, we focused on TCM's therapeutic effects and gut microbiome's mediation roles, including the relationships among diet, gut microbiome, and health care. Third, we have summarized some databases and tools to help understand the impact of TCM and gut microbiome on diagnosis and treatment at the molecular level. Finally, we introduce the effects of gut microbiome on TCM and host health, with two case studies, one on the metabolic effect of gut microbiome on TCM, and another on cancer treatment. In summary, we have reviewed the current status of the two components of healthcare: TCM and gut microbiome, as well as their concert effects. It is quite clear that as the holobiont, the maintenance of the health status of human would depend heavily on TCM, gut microbiome, and their combined effects.

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Microbiome in Colorectal Cancer: How to Get from Meta-omics to Mechanism?

Cited by 161 publications

References 165 publications

Salivary Microbiota for Gastric Cancer Prediction: An Exploratory Study

Salivary Microbiota for Gastric Cancer Prediction: An Exploratory Study

Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment

Traditional Chinese Medicine and Gut Microbiome: Their Respective and Concert Effects on Healthcare

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