2021
DOI: 10.3390/ijms22147600
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Abstract: Phthalides are bioactive compounds that naturally occur in the family Apiaceae. Considering their potentially versatile applications, it is desirable to determine their physical properties, activity and metabolic pathways. This study aimed to examine the utility of whole-cell biocatalysts for obtaining 3-butyl-3-hydroxyphthalide, which is the metabolite formulated during mammalian metabolism of 3-n-butylidenephthalide. We performed transformations using 10 strains of fungi, five of which efficiently produced 3… Show more

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Cited by 7 publications
(1 citation statement)
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“…3- n -Butylphthalide (NBP) is a natural compound approved by the Chinese National Administration of Medical Products for treating ischaemic stroke [ 30 , 31 , 32 , 33 , 34 ]. Repeated studies have shown that the NBP demonstrated multidirectional neuroprotective effects in ischaemic conditions.…”
Section: Introductionmentioning
confidence: 99%
“…3- n -Butylphthalide (NBP) is a natural compound approved by the Chinese National Administration of Medical Products for treating ischaemic stroke [ 30 , 31 , 32 , 33 , 34 ]. Repeated studies have shown that the NBP demonstrated multidirectional neuroprotective effects in ischaemic conditions.…”
Section: Introductionmentioning
confidence: 99%