Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome

Abstract

he earliest known case of SARS-CoV-2 infection causing COVID-19 is thought to have occurred on 17 November 2019 (ref. 1 ). As of 3 August 2021, 198.7 million confirmed cases of COVID-19 and 4.2 million deaths have been reported worldwide 2 . As the global scientific community has rallied in a concerted effort to understand SARS-CoV-2 infections, our background knowledge

Impact of asthma on COVID-19 mortality in the United States: Evidence based on a meta-analysis

“…After evaluating and assessing as much as 257 potential studies, 201 studies were removed due to outcome of interest being not available. In the end, what underlay this meta-analysis were eligible fifty-six articles with 426,261 COVID-19 patients [5] , [6] , [7] , [8] , [9] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] . The detail of selection process is shown by a chart flow in Figure 1 .…”

Oral Prevotella Species and Their Connection to Events of Clinical Relevance in Gastrointestinal and Respiratory Tracts

“…Among 164 patients with various types of symptoms, increased abundances of several Prevotella species were among the top predicting taxa from swabs of the posterior oropharynx: P. denticola , P. nigrescens , P. histicola , and P. oulorum in the patient group with ongoing symptoms, and P. denticola , P. melaninogenica , P. jejuni , and P. nigrescens in the determined long-COVID group ( Haran et al, 2021 ). Sulaiman et al (2021) examined a hospitalized cohort of 589 critically ill COVID-19 patients, characterizing their lung microbiome from bronchoalveolar lavage samples. Especially interesting were the findings of two oral commensals, P. oris and Mycoplasma salivarium , among the most dominant, functionally active microbial taxa.…”

2021 in review

“…As for COVID-19 pathogenesis, respiratory failure has been associated with increased mortality, and one study showed that in the lungs, SARS-CoV-2 load, anti-SARS-CoV-2 antibody responses and the microbiota are predictive of poor outcomes in patients who are severely ill with COVID-19 (ref. 2 ). With regards to therapeutics, one in vivo study in ferrets reported prophylactic and infection-limiting efficacy for a promising oral SARS-CoV-2 antiviral, molnupiravir 3 , which is currently in phase 2/3 clinical trials (NCT04575597).…”