Microbial production of 1,3-propanediol by Klebsiella pneumoniae using crude glycerol from biodiesel preparations

Mu, Ying; Teng, Hu; Zhang, Dai-Jia; Wang, Wei; Xiu, Zhilong

doi:10.1007/s10529-006-9154-z

Cited by 250 publications

(128 citation statements)

References 12 publications

(12 reference statements)

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“…CG could be transformed via anaerobic fermentation by Klebsiella pneumoniae 1,3-propanediol, which can be an excellent raw material for producing polyesters and polyurethanes [14]. Large scale production of 1,3-propanediol (1,3-PDO) by K. pneumoniae M5al was done in step-wise manner, in reactors ranging from 5 to 5000 L capacity.…”

Section: Propanediolsmentioning

confidence: 99%

Biorefinery for Glycerol Rich Biodiesel Industry Waste

2016

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The biodiesel industry has the potential to meet the fuel requirements in the future. A few inherent lacunae of this bioprocess are the effluent, which is 10 % of the actual product, and the fact that it is 85 % glycerol along with a few impurities. Biological treatments of wastes have been known as a dependable and economical direction of overseeing them and bring some value added products as well. A novel eco-biotechnological strategy employs metabolically diverse bacteria, which ensures higher reproducibility and economics. In this article, we have opined, which organisms and what bioproducts should be the focus, while exploiting glycerol as feed.

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Section: Propanediolsmentioning

confidence: 99%

Biorefinery for Glycerol Rich Biodiesel Industry Waste

2016

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“…Furthermore, it should be noted that microbial metabolic modeling, primarily in the form of MFA, is also being pursued in alternative production organisms, such as Klebsiella pneumoniae (Chi et al, 2003;Cheng et al, 2006;Liu et al, 2007;Mu et al, 2006;Zhang et al, 2008).…”

Section: Recently Launched: 13-propanediolmentioning

confidence: 99%

Industrial systems biology

Otero

Nielsen

2009

Biotech & Bioengineering

132

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ABSTRACT:The chemical industry is currently undergoing a dramatic change driven by demand for developing more sustainable processes for the production of fuels, chemicals, and materials. In biotechnological processes different microorganisms can be exploited, and the large diversity of metabolic reactions represents a rich repository for the design of chemical conversion processes that lead to efficient production of desirable products. However, often microorganisms that produce a desirable product, either naturally or because they have been engineered through insertion of heterologous pathways, have low yields and productivities, and in order to establish an economically viable process it is necessary to improve the performance of the microorganism. Here metabolic engineering is the enabling technology. Through metabolic engineering the metabolic landscape of the microorganism is engineered such that there is an efficient conversion of the raw material, typically glucose, to the product of interest. This process may involve both insertion of new enzymes activities, deletion of existing enzyme activities, but often also deregulation of existing regulatory structures operating in the cell. In order to rapidly identify the optimal metabolic engineering strategy the industry is to an increasing extent looking into the use of tools from systems biology. This involves both x-ome technologies such as transcriptome, proteome, metabolome, and fluxome analysis, and advanced mathematical modeling tools such as genome-scale metabolic modeling. Here we look into the history of these different techniques and review how they find application in industrial biotechnology, which will lead to what we here define as industrial systems biology.

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“…Biodiesel can replace petroleum diesel, as it is produced from animal fats and vegetable oils, however about 10% of final product results in glycerol as the main byproduct ( Figure 1) [5]. In some European countries, the production of glycerol has increased significantly due to biodiesel uptake.…”

Section: Introductionmentioning

confidence: 99%

Bioconversion of Commercial and Waste Glycerol into Value-Added Polyhydroxyalkanoates by Bacterial Strains

Castro¹

2014

J Microb Biochem Technol

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The industrial conversion of renewable resources into bio-based materials has been increasingly receiving attention from an economic and, in particular, an environmental point of view. Among these bioresources, glycerol represents one of the most important base materials for the manufacturing of bulk and higher-valued products. This is mainly based on the increasing amounts of waste glycerol due to the rising production of biodiesel and other oleochemicals, as well as on the applicability of glycerol as a water-soluble carbon source for a wide range of microbial productions. Polyhydroxyalkanoates (PHAs) are biodegradable and environmentally friendly biopolymers, and the major contributor to PHA production is the substrate cost, therefore it is desirable to produce PHA from waste residues like biodiesel byproducts. Since soil ecosystems have a rich, but still insufficiently studied microbial flora, the ability of bacteria isolated from Finnish soils and sediments were investigated for the production of valueadded materials such as Polyhydroxyalkanoates based on pure and waste glycerol as carbon source. 1 out of 40 isolated strains was selected for further studies based on ability to produce PHA on mineral medium and identified as Halomonas sp SA8 with up to 56% of Polyhydroxyalkanoate accumulation. The produced biopolymer was recovered and identified as PHB homopolymer.

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Microbial production of 1,3-propanediol by Klebsiella pneumoniae using crude glycerol from biodiesel preparations

Cited by 250 publications

References 12 publications

Biorefinery for Glycerol Rich Biodiesel Industry Waste

Biorefinery for Glycerol Rich Biodiesel Industry Waste

Industrial systems biology

Bioconversion of Commercial and Waste Glycerol into Value-Added Polyhydroxyalkanoates by Bacterial Strains

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