Microbial ecology of Scardovia wiggsiae-positive and negative samples

Tam, Amy; Kingsley, Karl

doi:10.24262/jsd.1.2.17015

Cited by 1 publication

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“…Second, the analysis of prevalence from this study found many more SW-positive s among pediatric orthodontic patients compared with either adult or pediatric non patients, which may suggest this population may be at higher risk for SW-related caries or other negative oral health outcomes [37]. Whether this is related to hygiene or other influences related to orthodontic treatment is not within the scope of this study but are factors that should be further explored in future studies to determine why this observation has been made in several studies of this nature [22][23][24][25][26][27][28][29]38]. In addition, the Second, the analysis of prevalence from this positive samples among pediatric orthodontic patients compared with either adult or pediatric non-Orthodontic patients, which may suggest this population may related caries or other negative oral health outcomes [37].…”

Section: (Ss) Screening For Ss Dna Revealed the Majority Of Samples mentioning

confidence: 99%

“…Further research has attempted to determine prevalence among orthodontic and nonorthodontic patients, including pediatric and adult populations [23][24][25]. In addition, a few of these studies have now attempted to survey the microbial ecology to determine the additional microbial constituents that may be important to the development of SW prevalence, such as SM [26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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Scardovia wiggsiae and Streptococcus sobrinus Prevalence among Orthodontic and Non-Orthodontic Patients

Trumbo

Kim

Samiano

et al. 2021

MRJI

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Background: Dental cavities or caries have been identified as among the most prevalent of preventable oral conditions. However, studies are discovering new information regarding the incidence and prevalence of several cariogenic organisms, including Streptococcus mutans (SM), the recently discovered Scardovia wiggsiae (SW), as well as Streptococcus sobrinus (SS). These studies have revealed varying prevalence among different populations, such as those undergoing orthodontic treatment. Based upon this information, the main goal of the current study was to assess the prevalence of specific cariogenic organisms (SS and SW) within saliva samples originally obtained from a dental school-based clinic. Methods: The protocol for this retrospective study of DNA isolated from previously collected saliva samples was reviewed and approved by the Institutional Review Board (IRB) as exempt research. In brief, clinical DNA samples were screened for SS and SW using quantitative polymerase chain reaction (qPCR). Demographic and subgroup (Orthodontic, non-Orthodontic) analysis was also performed. Results: This study found that pediatric (12-17 year old patient) samples were much more likely to harbor either SW or SS compared with adult (>18 year old patient) samples. In addition, this study found many more SW-positive samples among pediatric orthodontic patients compared with either adult or pediatric non-Orthodontic patients, which may suggest this population may be at higher risk for SW-related caries or other negative oral health outcomes. Finally, this study found these microbial populations to be strongly linked within the same patient samples. Conclusions: This study has demonstrated that prevalence of SW and SS may be more highly associated with specific population subgroups, including SS observed in non-orthodontic patients and SW found among pediatric orthodontic patients. These results also differ from previous evidence, which found only minor and partially overlapping prevalence of these and other oral microbes. The results of this current study may suggest that SS and SW may be more strongly correlated within similar oral microbial communities and their presence may be directly or indirectly linked through one or more behavioral, microbial or other factors – although more research will be needed to determine these mechanisms.

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