Microbial degradation of .ALPHA.-picolinic acid, 2-pyridinecarboxylic acid.

Ohsugi, Masahiro; Inoue, Yūta; Takami, Keiko; Namikawa, Mayumi

doi:10.1271/bbb1961.45.1879

Cited by 3 publications

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“…Tate and Ensign (125,126) reported that picolinic acid-grown resting cells of Arthrobacter picolinophilus oxidized 6-hydroxypicolinic acid to carbon dioxide, ammonium, and water. Ohsugi et al (78) reported that a bacterium isolated from soil utilized 2-picolinic acid, producing dicarboxylic acids with two-, five-, six-, seven-, and nine-carbon chains. The authors suggested that these dicarboxylic acids were precursors in the biosynthesis of desthiobiotin and found that desthiobiotin was also produced during the transformation of 2-picolinic acid.…”

Section: -Carboxypyridinementioning

confidence: 99%

Microbial metabolism of pyridine, quinoline, acridine, and their derivatives under aerobic and anaerobic conditions.

Kaiser

Feng

Bollag

1996

Microbiological Reviews

185

131

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Section: -Carboxypyridinementioning

confidence: 99%

Microbial metabolism of pyridine, quinoline, acridine, and their derivatives under aerobic and anaerobic conditions.

Kaiser

Feng

Bollag

1996

Microbiological Reviews

185

131

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Microbial metabolism of pyridine, quinoline, acridine, and their derivatives under aerobic and anaerobic conditions

1996

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Our review of the metabolic pathways of pyridines and aza-arenes showed that biodegradation of heterocyclic aromatic compounds occurs under both aerobic and anaerobic conditions. Depending upon the environmental conditions, different types of bacteria, fungi, and enzymes are involved in the degradation process of these compounds. Our review indicated that different organisms are using different pathways to biotransform a substrate. Our review also showed that the transformation rate of the pyridine derivatives is dependent on the substituents. For example, pyridine carboxylic acids have the highest transformation rate followed by mono-hydroxypyridines, methylpyridines, aminopyridines, and halogenated pyridines. Through the isolation of metabolites, it was possible to demonstrate the mineralization pathway of various heterocyclic aromatic compounds. By using 14C-labeled substrates, it was possible to show that ring fission of a specific heterocyclic compound occurs at a specific position of the ring. Furthermore, many researchers have been able to isolate and characterize the microorganisms or even the enzymes involved in the transformation of these compounds or their derivatives. In studies involving 18O labeling as well as the use of cofactors and coenzymes, it was possible to prove that specific enzymes (e.g., mono- or dioxygenases) are involved in a particular degradation step. By using H2 18O, it could be shown that in certain transformation reactions, the oxygen was derived from water and that therefore these reactions might also occur under anaerobic conditions.

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Biosynthesis of biotin-vitamers from unsaturated higher fatty acids by bacteria.

Ohsugi

Miyauchi

Inoue

1985

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Microbial degradation of .ALPHA.-picolinic acid, 2-pyridinecarboxylic acid.

Cited by 3 publications

References 1 publication

Microbial metabolism of pyridine, quinoline, acridine, and their derivatives under aerobic and anaerobic conditions.

Microbial metabolism of pyridine, quinoline, acridine, and their derivatives under aerobic and anaerobic conditions.

Microbial metabolism of pyridine, quinoline, acridine, and their derivatives under aerobic and anaerobic conditions

Biosynthesis of biotin-vitamers from unsaturated higher fatty acids by bacteria.

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