Microbial Baeyer–Villiger oxidation of steroidal ketones using Beauveria bassiana: Presence of an 11α-hydroxyl group essential to generation of D-homo lactones

Biotransformation of dehydroepiandrosterone (DHEA) by environmental strains of filamentous fungi

“…49 Additionally in the culture of Beauveria bassiana, Penicillium camemberti AM83 and P. lilacinum AM111 AD was transformed slower than DHEA into corresponding lactones. 42,48,50 Penicillium chrysogenum KCh S4. Transformations of DHEA in the culture of this strain proceeded according to the previously proposed pathway no.…”

Efficient hydroxylation of functionalized steroids by Colletotrichum lini ST-1

“…Furthermore, in all recorded cases, the activity of 11␣-hydroxylase was observed after 12-24 h, which suggested that this enzyme might be induced. Progesterone (7) was a commonly used steroid substrate [34,35], but only the monohydroxylation product 15␣-hydroxyprogesterone (15) with 27% yield (Table 5) was separated after cultivation with C. lini ST-1. The oxygen group in position C11 was regarded as essential for anti-inflammatory action [36].…”

Metabolism of steroidal lactones by the fungus Corynespora cassiicola CBS 161.60 results in a mechanistically unique intramolecular ring-D cyclization resulting in C-14 spiro-lactones

“…1 H NMR was used to follow the steroidal transformation [9,15,19,20] and thus enable the determination of the time sequence to the formation of the individual metabolites isolated in this study.…”