Microbes and healthful longevity

Erdman, Susan E.

doi:10.18632/aging.100969

Cited by 2 publications

(2 citation statements)

References 7 publications

(13 reference statements)

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“…Recent research has established that birth by C-section can result in different pattern of behaviour in humans [6][7][8] and in animals [9][10][11]. Recent discoveries point to a pivotal role for OXT in regulating general well-being through its influence on neuroimmune-endocrine pathways [57]. Here we demonstrate that pharmacological manipulation of the OXT system during the early postnatal period (P1-P5) improves social and anxiety-like behaviours, as well as the immune response later in life in the C-section mice model.…”

Section: Discussionmentioning

confidence: 99%

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Morais

Golubeva

Casey

et al. 2021

Neuropsychopharmacol.

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The oxytocin (OXT) system has been strongly implicated in the regulation of social behaviour and anxiety, potentially contributing to the aetiology of a wide range of neuropathologies. Birth by Caesarean-section (C-section) results in alterations in microbiota diversity in early-life, alterations in brain development and has recently been associated with long-term social and anxiety-like behaviour deficits. In this study, we assessed whether OXT intervention in the early postnatal period could reverse C-section-mediated effects on behaviour, and physiology in early life and adulthood. Following C-section or per vaginum birth, pups were administered with OXT (0.2 or 2 μg/20 μl; s.c.) or saline daily from postnatal days 1–5. We demonstrate that early postnatal OXT treatment has long-lasting effects reversing many of the effects of C-section on mouse behaviour and physiology. In early-life, high-dose OXT administration attenuated C-section-mediated maternal attachment impairments. In adulthood, low-dose OXT restored social memory deficits, some aspects of anxiety-like behaviour, and improved gastrointestinal transit. Furthermore, as a consequence of OXT intervention in early life, OXT plasma levels were increased in adulthood, and dysregulation of the immune response in C-section animals was attenuated by both doses of OXT treatment. These findings indicate that there is an early developmental window sensitive to manipulations of the OXT system that can prevent lifelong behavioural and physiological impairments associated with mode of birth.

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Section: Discussionmentioning

confidence: 99%

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Morais

Golubeva

Casey

et al. 2021

Neuropsychopharmacol.

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“…Another study by Varian et al (2016) showed that microbe monotherapy was sufficient to increase thymus gland size, inhibit intestinal polyp formation, and increase lifespan in mouse models [18]. The proposed immune mechanisms involved microbial up-regulation of transcription factor Forkhead box protein N1 (FoxN1), the protein that is entirely lacking in athymic nude mice rendering them without T lymphocytes and as a result highly permissive to cancer growth [18,19].…”

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confidence: 99%

Revisiting ‘what causes cancer?’

2017

Cancer Stud Ther J

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Microbes and healthful longevity

Cited by 2 publications

References 7 publications

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Revisiting ‘what causes cancer?’

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