2015
DOI: 10.1097/iop.0000000000000507
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Microanatomical Location of Hyaluronic Acid Gel Following Injection of the Temporal Hollows

Abstract: This study elucidates the location of hyaluronic acid gel after subcutaneous injection within the temporal hollow. Histology confirmed consistent placement of the gel within the subcutaneous tissues, but it also showed that injection in this region may produce unintended deeper location of filler, and a significant perivascular collection of the material. The proximity of dense temporal fascial and muscle arterial networks in this region may pose risk for perivascular injection and associated complications.

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Cited by 13 publications
(19 citation statements)
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“…15-17 While none of the gel was found within the superior labial artery, some sections demonstrated perivascular location of the product. Compression from gel filler may represent one mechanism of post-injection ischemia 13 , especially toward the midline where anastomoses diminish and where the nasal septal branches are more superficial. 1317 Augmentation of the medial lip should be approached with care.…”
Section: Discussionmentioning
confidence: 99%
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“…15-17 While none of the gel was found within the superior labial artery, some sections demonstrated perivascular location of the product. Compression from gel filler may represent one mechanism of post-injection ischemia 13 , especially toward the midline where anastomoses diminish and where the nasal septal branches are more superficial. 1317 Augmentation of the medial lip should be approached with care.…”
Section: Discussionmentioning
confidence: 99%
“…The tissue blocks were fixed in 95% alcohol for 12 days according to previously published methods studying the microanatomic location of HA gel. 11-13 The specimens were then embedded in paraffin and 4 μm sections were utilized for histologic analysis. The sections were stained with hematoxylin and eosin and examined under light microscopy to determine the histopathologic location of the HA gel.…”
Section: Methodsmentioning
confidence: 99%
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“…Autologous fat grafting is an approach used to contour the face, breast, and other body areas for cosmetic and/or reconstructive purposes. 10 Its advantages stem from low immunogenicity, low cost, malleability, accessibility, and induction of angiogenesis to promote tissue survival and long-term outcomes. 11,12 When used for temporal augmentation, intimate knowledge of neurovascular anatomy is necessary to avoid injury and complications.…”
Section: Fat Graftsmentioning
confidence: 99%