Micro and nanosystems for delivering local anesthetics

Paula, Eneida de; Cereda, Cíntia Maria Saia; Fraceto, Leonardo Fernandes; Araújo, Daniele Ribeiro de; Franz-Montan, Michelle; Tófoli, Giovana Radomille; Ranali, José; Volpato, Maria Cristina; Groppo, Francisco Carlos

doi:10.1517/17425247.2012.738664

Cited by 78 publications

(53 citation statements)

References 124 publications

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“…In these lipid vesicles, formed by the hydrophobic effect to maximize the interaction between the acyl chains, protecting them from the contact with the aqueous medium, the hydrophobic tails turn towards the inside of the lamella and the polar heads are exposed outward, in contact with water [69]. Due to the presence of an aqueous compartment and lipid bilayers, liposomes can incorporate hydrophilic and hydrophobic molecules, which is quite interesting for a drug carrier [70].…”

Section: Liposomesmentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: Liposomesmentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…Their glucopyranose units (6, 7, 8 for α, β and γ respectively) linked by α (1,4) linkages form a truncated cone with hydrophobic internal cavity, which accommodates hydrophobic drug moieties compatible with the cavity size (cavity size of 6.0–6.5 Å, in the case of β‐CD) . Regarding local anaesthetics, complexation with CDs has been shown to prolong the analgesia and decrease drug toxicity (see for a review). A recent study showed that OXZ‐γ‐CD complex largely improve OXZ aqueous solubility, but this type of CD is not recognised as safe for parenteral administration…”

Section: Introductionmentioning

confidence: 99%

Complexation of oxethazaine with 2-hydroxypropyl-β-cyclodextrin: increased drug solubility, decreased cytotoxicity and analgesia at inflamed tissues

Prado

Yokaichiya

Franco

et al. 2017

Journal of Pharmacy and Pharmacology

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“…However, in addition to pain relief, they produce side effects such as sedation, constipation, respiratory depression, euphoria, misuse, and addiction, which resulted in the opioid crisis. [17,18] Materials used for these structures are usually polyesters like polycaprolactone, polylactic acid, or poly(lactic-co-glycolic acid), and contain the local anesthetic either incorporated directly, or, in the case of the nanocapsules, dissolved in an oily core surrounded by the polymer. A prototypic κ-receptor selective agonist is U50,488H (U50), which has been shown to exert effective analgesia in animal pain models.…”

Section: Introductionmentioning

confidence: 99%

Tailor‐Made Core‐Multishell Nanocarriers for the Delivery of Cationic Analgesics to Inflamed Tissue

Unbehauen

Łabuz

Schwarzl

et al. 2019

Advanced Therapeutics

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U50,488H (U50) is a κ-opioid receptor agonist exerting effective analgesia in animal pain models. Yet, side effects such as sedation and depression-like symptoms mediated in the brain limit its therapeutic potential. In this study, tailor-made core-multishell (CMS) nanocarriers are presented containing U50 that, despite their small size, exhibit a pH-dependent retention effect via non-covalent interactions with the drug. The nanocarriers and their non-functionalized counterparts are characterized regarding their release properties in vitro, including a theoretical modeling of the release parameters which show the beneficial features of the additional functionalization. Finally, the U50-containing nanocarriers are tested in an in vivo rat model of inflammatory pain, with the results showing prolonged analgesic effect.

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Micro and nanosystems for delivering local anesthetics

Cited by 78 publications

References 124 publications

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Complexation of oxethazaine with 2-hydroxypropyl-β-cyclodextrin: increased drug solubility, decreased cytotoxicity and analgesia at inflamed tissues

Tailor‐Made Core‐Multishell Nanocarriers for the Delivery of Cationic Analgesics to Inflamed Tissue

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