Abstract:Prdx6؊/؊ macrophages had higher hydrogen peroxide levels, and lower survival rates; Prdx6 ؊/؊ mice had significantly lower survival rates, more severe tissue damage, and higher protein oxidation levels. Additionally, there were no differences in the mRNA expression levels of other peroxiredoxins, glutathione peroxidases, catalase, superoxide dismutases, thioredoxins, and glutaredoxins between normal Prdx6 ؊/؊ and Prdx6 ؉/؉ mice and those injected with paraquat. Our study provides in vivo evidence that PRDX6 is… Show more
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