2018
DOI: 10.1371/journal.pone.0195310 View full text |Buy / Rent full text
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Abstract: BackgroundInability to maintain a stable and beneficial microbiota is associated with chronic gut inflammation, which classically manifests as colitis but may more commonly exist as low-grade inflammation that promotes metabolic syndrome. Alterations in microbiota, and associated inflammation, can originate from dysfunction in host proteins that manage the microbiota, such as the flagellin receptor TLR5. That the complete absence of a microbiota (i.e. germfree conditions) eliminates all evidence of inflammatio… Show more

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“…Mice were fed autoclaved LabDiet rodent chow # 5021. ASF mice were established by colonizing WT C57BL/6 GF mice with the complete Altered Schaedler flora (8 strains) using feces purchased from ASF Taconic Biosciences Inc. and resuspended in drinking water, as previously described ( Chassaing and Gewirtz, 2018a ). Mice used in this study were 4-5 weeks old.…”
Section: Methodsmentioning
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“…Mice were fed autoclaved LabDiet rodent chow # 5021. ASF mice were established by colonizing WT C57BL/6 GF mice with the complete Altered Schaedler flora (8 strains) using feces purchased from ASF Taconic Biosciences Inc. and resuspended in drinking water, as previously described ( Chassaing and Gewirtz, 2018a ). Mice used in this study were 4-5 weeks old.…”
Section: Methodsmentioning
“…155,156 In addition, AIEC infection in mice also increased Il6 and Lcn2 mRNA expression, fecal lipocalin-2 content, and spleen weight. 108 Bretin and colleagues recently suggested that transient AIEC infection in mice can promote inflammatory signaling after clearance of the pathobiont. 136 These data demonstrate that pathobionts are able to induce stress responses and inflammatory signaling in IECs and may continue to promote inflammation long after infection.…”
Section: Activation Of Immune and Stress Responsesmentioning
“…(Hudson, NY), which contained the 8 ASF strains, to established Altered Schaedler Flora (ASF) mice as previously described [30]. Eight-week-old ASF male mice were fed with autoclaved chow and irradiated WSD for 1 week before infecting with 4×10 8 CFU/per mouse C. rodentium, and placed in isolated ventilated caging system (Isocage, Techniplast, Buguggiate VA, Italy) that prevents exogenous bacterial contamination.…”
Section: Gnotobiotic Mouse Experimentsmentioning