MICA Antigens Stimulate T Cell Proliferation and Cell-Mediated Cytotoxicity

HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

“…All three genes, that we studied, encoded molecules influenced in the immune response. HLA class II glycoproteins are responsible for initial step of the immune response and antigen presentation, stress-inducible MICA peptides may contribute to the Th2 immune reaction and induction of tolerance [17,18]. Prolactin like a cytokine modulates immune cells (T and dendritic cells) maturation and differentiation [32,33] and has direct effect to autoreactive B cells development [26].…”

“…The major histocompatibility complex class I chain -related gene A (MICA) is located 47 kb centromeric to the HLA-B locus [15] and encodes MICA protein which is expressed on the keratinocytes, endothelial cells and monocytes under the stress condition [16]. MICA peptide interacts with NKG2D/DAP10 receptor of the nature killers (NK) cells and receptor of the CD8 and δγ T lymphocytes and stimulates Th2 immune response [17,18,19]. MICA consists of the three extracellular domains, transmembrane segment (TM) and cytoplasmatic tail compound 383 amino acids polypeptide.…”

Anti-MICA Antibodies Are Related to Adverse Outcome in Heart Transplant Recipients

“…13,19 Because MICA antigens are highly polymorphic and are expressed on the surface of endothelial cells, they may be an important target for acute rejection. Zhang et al 15 reported that immunization of mice with MICA can produce a CD4 ϩ T-cell response and that MICAactivated CD8 ϩ T cells can cause cell-mediated cytotoxicity.…”

“…15 Thus, such antibodies may damage allografts. The effect of non-HLA antibodies for the long-term outcome of cardiac transplant recipients is poorly understood.…”

Importance of Non-HLA Gene Polymorphisms in Hematopoietic Stem Cell Transplantation

“…One of these blocks, the beta block, spans about 300 kb and contains the immunologically relevant HLA-B, HLA-C, MICA, and MICB genes (Kitcharoen et al, 2006). The polymorphic MICA molecule likely may be a target for specific antibodies and T cells in solid organ grafts or in GvHD (Zhang & Stastny, 2006).…”