volume 27, issue 6, P772-778 2013
DOI: 10.3109/02688697.2013.791664
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A. Gutenberg, H. C. Bock, W. Brück, L. Doerner, H. M. Mehdorn, W. Roggendorf, M. Westphal, J. Felsberg, G. Reifenberger, A. Giese

Abstract: The prognostic role of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation in glioblastoma patients treated with carmustine (BCNU) wafer implantation is unclear. Here, we report on a retrospective study of 47 patients with either newly diagnosed (30 patients) or recurrent (17 patients) glioblastoma (WHO grade IV) treated with BCNU (bis-chloroethylnitrosourea) wafers. Thirteen of the newly diagnosed patients received local BCNU and irradiation only (first-line BCNU), while 17 patients additiona…

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