2016
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Abstract: Chronic self-administration of nicotine induces maladaptive changes in the cortico-accumbal glutamate (Glu) network. Consequently, re-exposure to nicotine-associated cues raises extracellular Glu in the nucleus accumbens reinstating drug-seeking. Restoring basal concentrations of extracellular Glu, thereby increasing tonic activation of the presynaptic group II metabotropic Glu receptors (mGluR2/3) with N-acetylcysteine (N-AC), might offer a valid therapeutic approach for maintaining smoking abstinence. Althou… Show more

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citations
Cited by 16 publications
(36 citation statements)
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References 54 publications
(77 reference statements)
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“…The interactive effect of pre-session menthol administration as an occasion setter and discrete nicotine-conditioned cue is consistent with results that were obtained in rats that were trained to self-administer other drugs of abuse (e.g., cocaine and alcohol) or natural rewards (e.g., Cervo et al, 2013; Katner et al, 1999; Moro et al, 2016; Weiss et al, 2001). It could be postulated that pre-session menthol administration produced an interoceptive state (an occasion setter) that signaled the availability of nicotine reward and brought the rats into contact with the lever while the response-contingent presentation of the cue then served as conditioned reinforcement to support responding on the lever.…”
Section: Discussionsupporting
confidence: 86%
“…The interactive effect of pre-session menthol administration as an occasion setter and discrete nicotine-conditioned cue is consistent with results that were obtained in rats that were trained to self-administer other drugs of abuse (e.g., cocaine and alcohol) or natural rewards (e.g., Cervo et al, 2013; Katner et al, 1999; Moro et al, 2016; Weiss et al, 2001). It could be postulated that pre-session menthol administration produced an interoceptive state (an occasion setter) that signaled the availability of nicotine reward and brought the rats into contact with the lever while the response-contingent presentation of the cue then served as conditioned reinforcement to support responding on the lever.…”
Section: Discussionsupporting
confidence: 86%
“…Experiments in rats evaluating the effects of mGlu 2/3 activation on reinstatement of drug seeking by cues previously associated with drug self-administration show that mGlu 2/3 activation attenuates reinstated seeking of cocaine (Lu et al, 2007; Cannella et al, 2013), methamphetamine (Kufahl et al, 2013), alcohol (Zhao et al, 2006) and nicotine (Liechti et al, 2007; Moro et al, 2016). LY379268 also reduces context-induced reinstatement of heroin seeking (Bossert et al, 2004) and drug priming-induced reinstatement of methamphetamine seeking (Kufahl et al, 2013).…”
Section: Group II Metabotropic Glutamate Receptorsmentioning
confidence: 99%
“…However, strategies aimed at increasing extracellular glutamate levels in the brain during nicotine withdrawal have produced mixed effects on nicotine-seeking behavior. For example, systemic administration of N-acetylcysteine, a cystine pro-drug that increases the activity of the xCT resulting in increased extracellular glutamate levels, has been shown to attenuate [87] or have no effect [88] on the reinstatement of nicotine seeking. With regard to the clinical literature, N-acetylcysteine does not produce a therapeutically robust response in human smokers.…”
Section: Neurotransmitter Mechanisms Regulating Nicotine Seekingmentioning
confidence: 99%
“…Moreover, nicotine self-administration is associated with decreased mGlu2/3 receptor expression in the NAc shell [93]. Additional changes in the cysteine/glutamate exchange and glial glutamate exchange systems, important regulators of glutamate release, have also been observed after nicotine exposure [84, 86, 88]. For instance, acute activation of the cystine/glutamate exchange (xCT) system with N-acetylcysteine attenuates cue-induced nicotine reinstatement [87], effects that are mediated by mGluR 2/3 [88], although results describing the effective dose of N-acetylcysteine to suppress reinstatement are mixed.…”
Section: Neurophysiological Mechanisms Underlying Nicotine-seeking Bementioning
confidence: 99%
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