Metronidazole for eosinophilic pustular folliculitis in human immunodeficiency virus type 1-positive patients

Smith, K. J.

doi:10.1001/archderm.131.9.1089

Cited by 7 publications

(5 citation statements)

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“…Systemic corticosteroids and sulfones are considered to be the treatments of choice (17). Favorable re sults have also been reported with clofazimine, minocycline, isotretinoin, UVB, indomethacin acemetacin, cyclosporin, cetirizine, metronidazole, and interferon-y (17)(18)(19)(20)(21)(22)(23). In our patient, the skin lesions completely disappeared leaving brownish hyperpigmentation with topical corticosteroid ointment alone.…”

Section: Discussionsupporting

confidence: 51%

Eosinophilic Pustular Folliculitis (Ofuji's Disease) in Myelodysplastic Syndrome

Jang

Chung

Choi

et al. 1998

The Journal of Dermatology

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We describe a case of eosinophilic pustular folliculitis (EPF, Ofuji's disease) in a 12-year-old male who suffered from myelodysplastic syndrome. Bone marrow study revealed an increase in the eosinophil cell line without peripheral blood eosinophilia in our case. We suggest that the immunologic abberations ascribed to myelodysplastic syndrome and the increase in the eosinophil cell line in the bone marrow might play roles in the development of EPF in our case.

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Section: Discussionsupporting

confidence: 51%

Eosinophilic Pustular Folliculitis (Ofuji's Disease) in Myelodysplastic Syndrome

Jang

Chung

Choi

et al. 1998

The Journal of Dermatology

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“…11 Gram-negative organism with Gram-positive organelles with a striking resemblance to L. bucalis has been identi®ed in one biopsy around and invading the hair shaft of a patient with HIV-EF. 34 It was not, however, found in four other patients with biopsy-proven HIV-EF, although all four responded to treatment with metronidazole. In severely immunocompromised patients with consistently low CD4 counts opportunistic infec-tions¯ourish and an as yet unidenti®ed organism could prove to be the culprit.…”

Section: Bacterial Infectionmentioning

confidence: 89%

“…As previously stated, metronidazole was used in ®ve patients with biopsy-proven EF due to the discovery in one biopsy of an anaerobic organism similar in morphology to L. buccalis. 34 Doses of 250 mg three times daily were given for 3±4 weeks with complete clearance. Two patients relapsed after a few months but again responded to a further course.…”

Section: Treatmentmentioning

confidence: 99%

Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment

Fearfield¹,

Rowe

Francis

et al. 1999

Br J Dermatol

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The predominant itchy folliculitis associated with human immunodeficiency virus (HIV) infection appears to be an eosinophilic folliculitis (EF). This is characterized by lytic degeneration of sebaceous glands and an inflammatory infiltrate in which eosinophils and CD8+ T lymphocytes predominate. All patients have low CD4 counts and present late on in their HIV disease. Lesional distribution is mainly truncal, with a significant proportion also having facial involvement. Our prospective survey has shown that it is impossible to differentiate clinically between infective folliculitis and EF, and we recommend therefore that all cases are biopsied. We review the clinicopathological and immunological aspects of HIV-associated itchy folliculitis, in particular HIV-associated EF as well as current theories on pathogenesis and treatment. We suggest that HIV-associated EF is an autoimmune disease with the sebocyte or some constituent of sebum acting as the autoantigen.

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“…26 The number of male patients rose sharply in 1995, when four groups reported 22 male and 2 female patients in total. [27][28][29][30] The number of female patients increased in 2005 and 2006, when two groups reported 12 cases of IS/ HIV in total. 31,32 The proportion of non-Japanese male patients with IS/HIV was 100% until 1995, when the first two cases involving women were reported.…”

Section: Chronology Of Is/hivmentioning

confidence: 99%

Eosinophilic pustular folliculitis: The transition in sex differences and interracial characteristics between 1965 and 2013

Nomura

Katoh

Yamamoto

et al. 2015

The Journal of Dermatology

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Eosinophilic pustular folliculitis (EPF) is characterized by a non-infectious infiltration of eosinophils in the hair follicles. It has three variants: (i) classic EPF; (ii) immunosuppression-associated EPF, which herein is subdivided into HIV-associated (IS/HIV) and non-HIV-associated (IS/non-HIV); and (iii) infancy-associated EPF (I-EPF). The rarity of EPF has hindered our understanding of this entity. To examine the characteristics of EPF, with respect to age, sex, race, and chronology, published in case reports to date, we queried PubMed using the following terms: ("eosinophilic pustular folliculitis" [All Fields] OR "eosinophilic folliculitis" [All Fields]) AND ("1965/1/1" [PDAT]: "2013/12/31" [PDAT]). Additional Japanese cases were collected from Igaku Chuo Zasshi through Ichushi-Web, JDream III, and secondhand quotations from domestic periodicals published in Japan. Proceedings were excluded. The PubMed search produced 275 citations containing 358 cases of EPF (224 men, 132 women, and two of unspecified sex); these cases involved classic EPF (101 Japanese and 81 non-Japanese), IS/HIV (4 Japanese and 85 non-Japanese), IS/non-HIV (4 Japanese and 20 non-Japanese), and I-EPF (4 Japanese and 59 non-Japanese). Ichushi generated an additional 148 citations containing 207 cases of Japanese (148 men and 59 women), which included cases of classic EPF (181 cases), IS/HIV (14 cases), IS/non-HIV (9 cases), and I-EPF (3 cases). There was no sex difference in the classic EPF cases reported between 2003 and 2013, whereas IS/HIV, IS/non-HIV, and I-EPF were predominated by men. There is room for reconsideration of sex differences, particularly with regard to classic EPF. The rarity and specificity of I-EPF in Japan may reflect a state of uncertainty about this entity.

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Metronidazole for eosinophilic pustular folliculitis in human immunodeficiency virus type 1-positive patients

Cited by 7 publications

References 0 publications

Eosinophilic Pustular Folliculitis (Ofuji's Disease) in Myelodysplastic Syndrome

Eosinophilic Pustular Folliculitis (Ofuji's Disease) in Myelodysplastic Syndrome

Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment

Eosinophilic pustular folliculitis: The transition in sex differences and interracial characteristics between 1965 and 2013

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