“…In the literature, multiple methods have been described for analyzing MTZ in different biological matrices and with a wide application of HPLC. The quantification of MTZ using HPLC has been described for different matrices: human whole blood samples (Fonnes et al, 2020); subcutaneous plasma and microdialysate from humans (Dorn et al, 2019); plasma and bile fluid from humans (Yoon et al, 2020); muscle tissue, plasma, and microdialysate from humans (Karjagin et al, 2004); rat plasma (Sampaio et al, 2019); and blood, brain, and biliary microdialysate from rats (Tsai & Chen, 2003), in addition to human feces (Jeffery et al, 2017). However, there are no reports of the analytical method using HPLC to determine MTZ in peritoneal microdialysate and compare it with blood microdialysate from rats.…”