METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans

Löffler, Dennis; Landgraf, Kathrin; Rockstroh, Denise; Schwartze, J T; Dunzendorfer, H; Kieß, Wieland; Körner, Antje

doi:10.1038/ijo.2016.180

Cited by 45 publications

(38 citation statements)

References 21 publications

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“…Wang et al reported that serum Metrnl levels were increased in overweight and obese subjects when compared with subjects of normal weight, and it was significantly correlated with BMI [7]. Löffler et al also reported increased Metrnl expression in adipocytes in obese children compared with lean children [16]. Our findings contradict data obtained by Wang and Löffler.…”

Section: Discussioncontrasting

confidence: 89%

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Önalan

Cavlı

Doğan

et al. 2020

Endokrynologia Polska

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Introduction: Meteorin-like (Metrnl), also known as subfatin, is a recently discovered adipokine with a favourable effect on insulin sensitivity. Studies have shown lower Metrnl levels in obese patients. However, data on its circulating levels in type 2 diabetes mellitus (T2DM) patients are contradictory. This study aims to evaluate serum Metrnl levels in T2DM patients and determine the relationship between serum Metrnl levels and insulin resistance in these patients. Material and methods: This cross-sectional study was conducted among 150 participants. The study was carried out between June 2019 and December 2019 at the internal medicine outpatient clinic of a tertiary university hospital. The participants were divided into three groups: group 1 (control group, n = 50), group 2 (newly diagnosed T2DM, n = 50), and group 3 (long-standing diagnosed T2DM, n = 50). An enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of Subfatin (Metrnl), and the correlations of Metrnl level with anthropometric parameters, HOMA index, and biochemical measurements were assessed. Results: There was no statistically significant difference between the gender (p = 0.468) and age (p = 0.067) characteristics of the three groups. The Metrnl (subfatin) levels of the participants were as follows: control group-20.05 (1.56-103.78); newly diagnosed T2DM group-2.62 (1.25-103.78); and long-standing diagnosed T2DM group-2.01 (0.80-19.84) pg/mL. The Metrnl (subfatin) levels of the participants in the control group were higher than in the participants in the newly diagnosed T2DM and long-standing diagnosed T2DM groups (p < 0.001). Subfatin demonstrated a negative correlation with insulin and HOMA-IR in the control group and long-standing diagnosed T2DM group. Conclusions: The subfatin level was found to be higher in the healthy control group than in both diabetic patient groups. Subfatin level showed negative correlation with both insulin level and HOMA index. There was a relationship between subfatin and insulin resistance. Low levels of subfatin in the diabetic patient groups may play a role in the pathogenesis of T2DM by increasing insulin resistance.

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Section: Discussioncontrasting

confidence: 89%

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Önalan

Cavlı

Doğan

et al. 2020

Endokrynologia Polska

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“…9) Our previous studies showed that Metrnl is highly expressed in white adipose tissue in both rodents and humans and plays important roles in adipose biology. 3,7) Recently, in line with our animal results, Löffler et al 10) showed that Metrnl expression is higher in subcutaneous adipocytes of obese children when compared with lean children and is associated with adipocyte size.…”

supporting

confidence: 75%

Evaluation of Two Commercial Enzyme-Linked Immunosorbent Assay Kits for the Detection of Human Circulating Metrnl

Zheng

Zhang

et al. 2018

Chem. Pharm. Bull.

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“…However, our results go beyond those of Li et al's study, which showed no significant association of Metrnl with BMI, TC, glucose, or TG in human subjects undergoing a physical examination. Loffler et al reported that Metrnl expression in adipocytes was higher in obese children compared to lean children. The discrepancies in these studies might be due to several potential factors including study design, ethnicity, sample size, patient characteristics, and concomitant disease.…”

Section: Discussionmentioning

confidence: 98%

Serum Metrnl is associated with the presence and severity of coronary artery disease

Liu

Yao

et al. 2018

J Cellular Molecular Medi

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Meteorin‐like (Metrnl) is a novel adipokine that is highly expressed in white adipose tissue. Metrnl stimulates energy expenditure and improves glucose tolerance in rodents. However, whether Metrnl plays a role in coronary artery disease (CAD) remains to be elucidated. The present study aimed to investigate the association of serum Metrnl with CAD in Chinese patients. A total of 193 patients with CAD and 156 control subjects were enrolled in this study. Serum Metrnl concentration was measured by enzyme‐linked immunosorbent assay. Anthropometric phenotypes, fasting glucose, serum lipids, and inflammatory cytokines were measured. Serum Metrnl was lower in CAD patients when compared to those controls (132.41 vs 173.17 pg/mL, P < 0.001). Serum Metrnl was negatively correlated with metabolic parameters, including body mass index, total cholesterol, and low‐density lipoprotein cholesterol as well as inflammatory markers including high‐sensitivity C‐reactive protein, IL‐1β, and IL‐11 even after adjustment for potential confounding variables (P < 0.05). In multivariable logistic regression analyses, compared to those in the highest tertile of serum Metrnl levels, subjects in the lowest tertile had the highest risks for CAD (adjusted OR = 2.63, 95% CI = 1.46‐4.27, P = 0.001). After adjustment for potential confounding variables, serum Metrnl was also decreased as the number of stenosed vessels increased (P < 0.001). Furthermore, decreased Metrnl level was negatively correlated with the severity of CAD quantified by the Gensini score. This first case‐control study shows significant associations of serum Metrnl with the presence and severity of CAD, suggesting Metrnl might be a new promising therapeutic target for CAD.

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METRNL decreases during adipogenesis and inhibits adipocyte differentiation leading to adipocyte hypertrophy in humans

Cited by 45 publications

References 21 publications

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Low serum levels of meteorin-like/subfatin: an indicator of diabetes mellitus and insulin resistance?

Evaluation of Two Commercial Enzyme-Linked Immunosorbent Assay Kits for the Detection of Human Circulating Metrnl

Serum Metrnl is associated with the presence and severity of coronary artery disease

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