Metoclopramide Enhances the Effect of Photodynamic Therapy on Xenografted Human Squamous Cell Carcinoma of the Head and Neck

Photodynamic effects of anthracyclin derivatives on squamous cell carcinoma cell lines of the head and neck

“…In the recent years, cytostatics have been applied more frequently as photosensitizers in order to improve the effectiveness of the photodynamic therapy. The first in vitro and in vivo examinations were very encouraging [7][8][9]. Examinations concerning the synergistic effect of photodynamic therapy and cyotstatics on squamous cell carcinoma cell lines have only been performed sporadically [31].…”

N-substituted benzamides inhibit NFκB activation and induce apoptosis by separate mechanisms

“…This is interesting since MCA is already used in the clinic as an antiemetic with both local and systemic effects (Harrington et al, 1983). Furthermore, both MCA and 3-CPA have been implicated as potential sensitizers of radio/chemo-therapies and phase 1-3 clinical trials are in progress (Kjellen et al, 1989(Kjellen et al, , 1995Lybak et al, 1990;Lybak and Pero, 1991;Hua et al, 1995, Werning et al, 1995. Whether this in vivo activity is due to the ability of direct induction of apoptosis by MCA or 3-CPA, or correlates with their ability to inhibit NFκB activation, remains to be established.…”

“…Some of these molecules, e.g. declopramide (3-CPA) and metoclopramide (MCA) have previously been studied in vitro, in vivo and in clinical models (Kjellen et al, 1989(Kjellen et al, , 1995Lybak et al, 1990;Lybak and Pero, 1991;Hua et al, 1995Werning et al, 1995;Olsson et al, 1997;Pero et al, 1998), and have been shown to be biologically active.…”

Nano-machining of silicon phthalocyanine dichloride films on H-passivated Si(111)

“…They have been used extensively as inexpensive, non-toxic pigments and dyes [3]. It has also been reported that phthalocyanine derivatives have potential as photosensitizers for the photodynamic therapy (PDT) of cancer [4][5][6][7][8][9][10][11] and as the active elements in chemical sensors, optoelectronic devices and solar cells [1]. Silicon phthalocyanine derivatives, together with some metal phthalocyanines, also form electronic conducting molecular crystals [12,13] if the organic molecules are stacked faceto-face in a form of 'partial oxidation' and co-axially provide a contiguous pathway for carrier delocalization.…”