Metoclopramide as Prophylaxis for Nausea and Vomiting Induced by Fluorescein

Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography

“…Some authors carried out a study with 100 patients comparing intravenous metoclopramide and a placebo and observed 11 (22%) cases of nausea or vomiting in the placebo group and 3 (6%) with this medication (20) . This study presented the limitation that the incidence of nausea in the placebo group was higher than that observed in literature (6)(7)(8) , a fact that was explained by the authors as a result of the used methodology where the patient was stimulated to communicate any evidence of nausea (20) . Metoclopramide constitutes the archetype of selective antagonists of dopamine, called substitute benzamide and has a powerful peripheral cholinergic effect that intensifies gastric emptiness.…”

“…In addition, a reduction of the incidence of nausea with the heating of the contrast was not observed (18) . Only two random clinical trials exist to discuss the use of medicines for nausea and vomiting prophylaxis in fluorescein angiography, where granisetron and metoclopramide have respectively been used (19)(20) . Some authors carried out a study with 120 patients comparing oral granisetron and a placebo and they observed 3 (5%) cases of vomiting in the placebo group and none with this medication.…”

Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography

“…Some authors carried out a study with 100 patients comparing intravenous metoclopramide and a placebo and observed 11 (22%) cases of nausea or vomiting in the placebo group and 3 (6%) with this medication (20) . This study presented the limitation that the incidence of nausea in the placebo group was higher than that observed in literature (6)(7)(8) , a fact that was explained by the authors as a result of the used methodology where the patient was stimulated to communicate any evidence of nausea (20) . Metoclopramide constitutes the archetype of selective antagonists of dopamine, called substitute benzamide and has a powerful peripheral cholinergic effect that intensifies gastric emptiness.…”

“…In addition, a reduction of the incidence of nausea with the heating of the contrast was not observed (18) . Only two random clinical trials exist to discuss the use of medicines for nausea and vomiting prophylaxis in fluorescein angiography, where granisetron and metoclopramide have respectively been used (19)(20) . Some authors carried out a study with 120 patients comparing oral granisetron and a placebo and they observed 3 (5%) cases of vomiting in the placebo group and none with this medication.…”

Adverse reactions of fluorescein angiography: a prospective study

“…In other studies, they ranged from 3% to 14% (6,9,(19)(20) . The pathophysiology of these effects involves the activation of chemical receptors in the vomiting nervous center located in the area postrema that function as primary detectors of emetic stimulation and induce vomiting through integration with vagal nerve or vestibular system (21) .…”

Adherence to diabetic eye examination guidelines in Australia: the National Eye Health Survey

“…Ipsilateral intravenous fluorescein injection is contraindicated in the setting of compromised lymphatic drainage after arm, breast, or axillary node dissection 470 . Prophylactic use of metoclopramide was reported to significantly reduce the incidence of nausea and vomiting 471 , though its use can also be associated with adverse effects.…”

Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography

“…Some authors carried out a study with 100 patients comparing intravenous metoclopramide and a placebo and observed 11 (22%) cases of nausea or vomiting in the placebo group and 3 (6%) with this medication (20) . This study presented the limitation that the incidence of nausea in the placebo group was higher than that observed in literature (6)(7)(8) , a fact that was explained by the authors as a result of the used methodology where the patient was stimulated to communicate any evidence of nausea (20) . Metoclopramide constitutes the archetype of selective antagonists of dopamine, called substitute benzamide and has a powerful peripheral cholinergic effect that intensifies gastric emptiness.…”

“…In addition, a reduction of the incidence of nausea with the heating of the contrast was not observed (18) . Only two random clinical trials exist to discuss the use of medicines for nausea and vomiting prophylaxis in fluorescein angiography, where granisetron and metoclopramide have respectively been used (19)(20) . Some authors carried out a study with 120 patients comparing oral granisetron and a placebo and they observed 3 (5%) cases of vomiting in the placebo group and none with this medication.…”

Adverse reactions of fluorescein angiography: a prospective study

“…In other studies, they ranged from 3% to 14% (6,9,(19)(20) . The pathophysiology of these effects involves the activation of chemical receptors in the vomiting nervous center located in the area postrema that function as primary detectors of emetic stimulation and induce vomiting through integration with vagal nerve or vestibular system (21) .…”

Adherence to diabetic eye examination guidelines in Australia: the National Eye Health Survey

“…Ipsilateral intravenous fluorescein injection is contraindicated in the setting of compromised lymphatic drainage after arm, breast, or axillary node dissection 470 . Prophylactic use of metoclopramide was reported to significantly reduce the incidence of nausea and vomiting 471 , though its use can also be associated with adverse effects.…”

Influence of bromopride in the prophylaxis of nausea associated with fluorescein angiography

“…Some authors carried out a study with 100 patients comparing intravenous metoclopramide and a placebo and observed 11 (22%) cases of nausea or vomiting in the placebo group and 3 (6%) with this medication (20) . This study presented the limitation that the incidence of nausea in the placebo group was higher than that observed in literature (6)(7)(8) , a fact that was explained by the authors as a result of the used methodology where the patient was stimulated to communicate any evidence of nausea (20) . Metoclopramide constitutes the archetype of selective antagonists of dopamine, called substitute benzamide and has a powerful peripheral cholinergic effect that intensifies gastric emptiness.…”

“…In addition, a reduction of the incidence of nausea with the heating of the contrast was not observed (18) . Only two random clinical trials exist to discuss the use of medicines for nausea and vomiting prophylaxis in fluorescein angiography, where granisetron and metoclopramide have respectively been used (19)(20) . Some authors carried out a study with 120 patients comparing oral granisetron and a placebo and they observed 3 (5%) cases of vomiting in the placebo group and none with this medication.…”

Adverse reactions of fluorescein angiography: a prospective study

“…In other studies, they ranged from 3% to 14% (6,9,(19)(20) . The pathophysiology of these effects involves the activation of chemical receptors in the vomiting nervous center located in the area postrema that function as primary detectors of emetic stimulation and induce vomiting through integration with vagal nerve or vestibular system (21) .…”

Adherence to diabetic eye examination guidelines in Australia: the National Eye Health Survey

“…Ipsilateral intravenous fluorescein injection is contraindicated in the setting of compromised lymphatic drainage after arm, breast, or axillary node dissection 470 . Prophylactic use of metoclopramide was reported to significantly reduce the incidence of nausea and vomiting 471 , though its use can also be associated with adverse effects.…”