2020
DOI: 10.1093/cid/ciaa1177
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Abstract: Background Steroid use for COVID-19 is based on the possible role of these drugs in mitigating the inflammatory response, mainly in the lungs, triggered by SARS-CoV-2. This study aimed at evaluating at evaluating the efficacy of methylprednisolone (MP) among hospitalized patients with suspected COVID-19. Methods Parallel, double-blind, placebo-controlled, randomized, phase IIb clinical trial was performed with hospitalized pa… Show more

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Cited by 360 publications
(417 citation statements)
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“…Thus, although the analysis included a high number of potentially predictive variables in the initial multivariate Cox models, it is possible that some unidentified confounder may have influenced our results. We also had a low number of patients meeting the final endpoints compared with other studies [12][13][14]16]. A possible explanation for this is that, despite the high pressure attained, our hospital did not collapse as many others in Spain.…”
Section: Limitationsmentioning
confidence: 84%
See 3 more Smart Citations
“…Thus, although the analysis included a high number of potentially predictive variables in the initial multivariate Cox models, it is possible that some unidentified confounder may have influenced our results. We also had a low number of patients meeting the final endpoints compared with other studies [12][13][14]16]. A possible explanation for this is that, despite the high pressure attained, our hospital did not collapse as many others in Spain.…”
Section: Limitationsmentioning
confidence: 84%
“…room air or need for non-invasive or invasive ventilation reported no benefit from the use of methyl-prednisolone [16]. They were treated with methyl-prednisolone, 0.5 mg/kg/12h, or placebo for five days.…”
Section: Plos Onementioning
confidence: 99%
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“…Adding further caution to the use of steroids in COVID-19, an even more recent randomised, placebo-controlled, double-blind study of 0.5 mg/kg of methylprednisolone conducted in Brazil in 393 patients found no difference in 28-day mortality and patients on steroids required more insulin therapy [18]. In a modified intention to treat analysis (excluding patients randomised but who never received a first dose of steroids or placebo), Jeronimo et al [18] observed that 28-day mortality was 38.2% in the placebo group and 37.1% in the methylprednisolone group (p = 0.629). Mortality at day 7 showed a trend to better outcomes with steroids (16.5% vs 23.6%, p = 0.089) but this had largely reversed by day 14 (27.3% vs 31.7%, p = 0.29).…”
Section: Digital Featuresmentioning
confidence: 99%