2015
DOI: 10.1073/pnas.1522301112
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Abstract: Phosphate (Pi) availability is a significant limiting factor for plant growth and productivity in both natural and agricultural systems. To cope with such limiting conditions, plants have evolved a myriad of developmental and biochemical strategies to enhance the efficiency of Pi acquisition and assimilation to avoid nutrient starvation. In the past decade, these responses have been studied in detail at the level of gene expression; however, the possible epigenetic components modulating plant Pi starvation res… Show more

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Cited by 166 publications
(175 citation statements)
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“…Supporting this assumption is that about 50% (1047 genes) of the promoter DMGs are in fact located within 5 kb upstream or downstream of differentially methylated TEs. The influence of methylation status of TEs on the transcriptional activity of nearby genes has been documented in a number of recent studies (Calarco et al, 2012;Secco et al, 2015;Yong-Villalobos et al, 2015;Zhang et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
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“…Supporting this assumption is that about 50% (1047 genes) of the promoter DMGs are in fact located within 5 kb upstream or downstream of differentially methylated TEs. The influence of methylation status of TEs on the transcriptional activity of nearby genes has been documented in a number of recent studies (Calarco et al, 2012;Secco et al, 2015;Yong-Villalobos et al, 2015;Zhang et al, 2015).…”
Section: Discussionmentioning
confidence: 99%
“…CG methylation frequently occurs in gene body regions, whereas CHG and CHH methylation are mostly found in TEs and other repetitive sequences (Cokus et al, 2008;Lister et al, 2008;Schmitz et al, 2011;Rambani et al, 2015;Yong-Villalobos et al, 2015;Zhang et al, 2015;Kawakatsu et al, 2016). While the functional role of gene body methylation is not fully understood, it has been suggested that methylation in the gene body may fine-tune transcriptional activity, regulate alternative splicing efficiency, and inhibit aberrant transcription of long transcripts (Zilberman et al, 2007;Luco et al, 2010;Maunakea et al, 2010;Regulski et al, 2013;Rambani et al, 2015).…”
mentioning
confidence: 99%
“…In the referenced study, 14 we proposed a model where in response to phosphate starvation a specific DNA methylation program is triggered in which differential methylation at gene features correlate with changes of expression of phosphate starvation responsive genes. Here we report that in the case of several Pi-starvation responsive genes, differential methylation occurs in the vicinity of binding sites motifs of TFs known to be directly involved in the low Pi response of Arabidopsis.…”
Section: Resultsmentioning
confidence: 99%
“…In a recent work, 14 we reported that Arabidopsis plants in Low Pi availability an extensive remodeling of global DNA methylation takes place, which in many cases correlated with changes in gene expression. Modifications in global methylation patterns within genic regions was highly correlated with transcriptional activation or repression, revealing an important role of dynamic methylation changes in modulating the expression of genes in response to Pi starvation.…”
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confidence: 89%
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