2005
DOI: 10.1007/s00280-005-1014-3 View full text |Buy / Rent full text
|
|

Abstract: Methylene blue (MB) is a phenothiazine with radio and photosensitizing properties and anti-tumoral activity. Our group has shown that MB was capable of inhibiting the in vitro growth of erythroleukemic cells with multidrug resistance (MDR). However, there are no studies comparing the cytotoxicity of this molecule for normal and tumoral cells. In this work, the cytotoxicity of MB was measured by MTT method in erythroleukemic and melanoma lineages, comparing it with that of normal cells:lymphocytes and melanocyt… Show more

Help me understand this report

Search citation statements

Order By: Relevance
Select...
1
1
1
1
1
14
0
1

Year Published

2007
2007
2009
2009

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

1
14
0
1
Order By: Relevance
“…Importantly, MB is currently used systemically for the treatment of urinary bladder infections and as an intravenous emergency medication for cyanide poisoning and the reversal of druginduced methemoglobinemia [19] suggesting the feasibility of administering these agents as systemic chemotherapeutic agents. Earlier reports have described cytotoxic effects of selected PRC compounds, which occur independent of their action as light-activated photodynamic agents [23,25]. Interestingly, some PRC compounds have high affinity for human tumor tissue in vivo, an effect that has been used earlier for experimental melanoma radiotherapy using single injections of 131 I-labeled MB [46].…”
Section: Discussionmentioning
See 1 more Smart Citation
Create an account to read the remaining citation statements from this report. You will also get access to:
  • Search over 1b+ citation statments to see what is being said about any topic in the research literature
  • Advanced Search to find publications that support or contrast your research
  • Citation reports and visualizations to easily see what publications are saying about each other
  • Browser extension to see Smart Citations wherever you read research
  • Dashboards to evaluate and keep track of groups of publications
  • Alerts to stay on top of citations as they happen
  • Automated reference checks to make sure you are citing reliable research in your manuscripts
  • 14 day free preview of our premium features.

Trusted by researchers and organizations around the world

Over 100,000 students researchers, and industry experts at use scite

See what students are saying

rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…Importantly, MB is currently used systemically for the treatment of urinary bladder infections and as an intravenous emergency medication for cyanide poisoning and the reversal of druginduced methemoglobinemia [19] suggesting the feasibility of administering these agents as systemic chemotherapeutic agents. Earlier reports have described cytotoxic effects of selected PRC compounds, which occur independent of their action as light-activated photodynamic agents [23,25]. Interestingly, some PRC compounds have high affinity for human tumor tissue in vivo, an effect that has been used earlier for experimental melanoma radiotherapy using single injections of 131 I-labeled MB [46].…”
Section: Discussionmentioning
“…Phenothiazinium redox dyes have diverse applications as biological redox indicators, vital stains and diagnostic dyes [17], modulators of mitochondrial respiration [18], infusional antidotes against cyanide poisoning and methemoglobinemia [19], antiinfective agents [20,21], and photosensitizers [22][23][24], but their therapeutic potential and mechanism of action as anti-cancer redox chemotherapeutics are largely unexplored [23,25]. Compounds containing the 3,7-diaminophenothiazinium redox pharmacophore including thionine (T, 3,7-diamino-phenothiazinium acetate), methylene blue (MB, 3,7-bis (dimethylamino)-phenothiazinium chloride), and toluidine blue O (TB, 2-methyl-3-amino-7-dimethylamino-phenothiazinium chloride) are two-electron redox systems with standard reduction potentials [e.g.…”
Section: Introductionmentioning
“…4-14) selectively target melanoma and other cancer cells with induction of mitochondrial apoptosis based on bioreductive activation and redox cycling (194,379). Remarkably, the phenothiazinium redox cycler (PRC) methylene blue is in clinical use worldwide as infusional redox antidote against cyanide poisoning and methemoglobinemia, a therapeutic application that suggests feasibility of systemic administration for investigational evaluation of potential oncological applications (48,219).…”
Section: 7-diaminophenothiazinium Redox Dyesmentioning
“…Um estudo comparativo da citotoxicidade do AM no escuro em células normais e tumorais verificou que esse corante é mais citotóxico em células tumorais 58,59 . O fato de que tanto células MDR como cepas de bactérias resistentes a múltiplos antibióticos também são sensíveis ao corante 6 sugere que AM pode ser usado como um agente quimioterapêutico.…”
Section: Fenotiazínicosunclassified